Inclusion Criteria:

1. Males and females ages 25 -75

2. If leukapheresis:

Hepatitis B surface antigen negative if tested* Hepatitis C antibody negative if
tested* HIV antibody negative if tested* VDRL negative if tested* No known IV drug
users HgB > 8.5 WBC > 3,800 Platelets > 120,000 INR < 2 (verified only if clinically
indicated)

3. If large blood draw (1/2 to 1 unit) in lieu of leukapheresis:

Hepatitis B surface antigen negative if tested* Hepatitis C antibody negative if tested*
HIV antibody negative if tested* VDRL negative if tested* No known IV drug users HgB >
10.0 WBC > 3,800 Platelets > 120,000 INR < 2 (verified only if clinically indicated)

Exclusion Criteria:

No known neurologic disease 2. No known CNS metastasis on clinical exam 3. No chemotherapy
within 1 month 4. No NYHA class III/IV status 5. No pulmonary disease which limits daily
activities 6. No anticoagulation therapy