Inclusion Criteria:

- age ≥ 18 years

- histologically confirmed solid or hematologic malignancy that is refractory to
standard therapy or for which no standard therapy exists

- estimated life expectancy > 12 weeks

- ECOG performance grade ≤ 2

- creatinine ≤ 1.5 X institutional upper limit of normal or creatinine clearance > 50
mL/min

- total bilirubin within institutional limits (unless elevated from documented
Gilbert's syndrome)

- AST and ALT ≤ 2.5 X institutional upper limit of normal (≤ 5 x institutional upper
limit of normal in the presence of liver metastases)

- platelet count ≥ 100,000/µL

- absolute neutrophil count (ANC) ≥ 1500/µL

- Hgb ≥ 9.0 g/dL

- patients with previously treated brain metastases who are not on corticosteroids are
eligible

- effective contraceptive method (e.g., intrauterine device, oral contraceptive, or
barrier device) must be used during the study by male and female patients of
childbearing potential

- ability to understand and willingness to sign a written informed consent

Exclusion Criteria:

- patients who have had immunotherapy, chemotherapy, or radiotherapy within 4 weeks
(within 6 weeks for nitrosoureas or mitomycin C) prior to study entry; study entry
defined as first day of drug dosing

- patients who have undergone major surgery within 4 weeks prior to study entry

- patients who are receiving another investigational drug

- patients with active CNS metastases or leptomeningeal disease not controlled by prior
surgery or radiotherapy

- uncontrolled illness including but not limited to: ongoing or active infection,
symptomatic congestive heart failure (New York Heart Association Class III or IV
heart failure), unstable angina pectoris, cardiac arrhythmia, and psychiatric illness
that would limit compliance with study requirements

- risk factors for QTc prolongation and/or Torsade de Pointes

- patients with known HIV infection

- concurrent systemic hormonal therapy except: stable LHRH agonist therapy for prostate
cancer; hormonal therapy (e.g., megestrol) for appetite stimulation; nasal,
ophthalmic, and topical glucocorticoid preparations when appropriate; stable oral
glucocorticoid and mineralocorticoid replacement for adrenal insufficiency; or oral
contraceptives

- patients who have other medical or psychiatric illness or organ dysfunction which, in
the opinion of the Investigator, would either compromise the patient's safety or
interfere with the evaluation of the safety of the study agent

- pregnant or lactating women (female patients must have a negative serum pregnancy
test within 7 days of study entry)

- patients who have previously received histone deacetylase inhibitors