The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer
- Collect blood samples for DNA extraction for genetic studies from patients receiving
chemotherapy for metastatic colorectal cancer.
- Collect detailed clinical, pathological, and chemotherapy data from these patients.
- Identify genetic factors that relate to treatment response and outcome in these
OUTLINE: Blood samples are collected and relevant genes and regions are amplified by PCR.
PCR products are then sequenced or genotyped for known biological markers and single
nucleotide polymorphisms. Tumor samples from surplus pathology specimens are analyzed for
expression of candidate genes and mutation in the candidate genes.
Clinical and family history data is also collected by questionnaire.
PROJECTED ACCRUAL: A total of 800 patients will be accrued for this study.
Angela Cox, PhD
University of Sheffield
United States: Federal Government