The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer
N/A
N/A
Both
Colorectal Cancer
Trial Information
The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer
OBJECTIVES:
- Collect blood samples for DNA extraction for genetic studies from patients receiving
chemotherapy for metastatic colorectal cancer.
- Collect detailed clinical, pathological, and chemotherapy data from these patients.
- Identify genetic factors that relate to treatment response and outcome in these
patients.
OUTLINE: Blood samples are collected and relevant genes and regions are amplified by PCR.
PCR products are then sequenced or genotyped for known biological markers and single
nucleotide polymorphisms. Tumor samples from surplus pathology specimens are analyzed for
expression of candidate genes and mutation in the candidate genes.
Clinical and family history data is also collected by questionnaire.
PROJECTED ACCRUAL: A total of 800 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of metastatic colorectal cancer
- Currently receiving chemotherapy at Weston Park Hospital
PATIENT CHARACTERISTICS:
- Not Specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Survival
Safety Issue:
No
Principal Investigator
Angela Cox, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
University of Sheffield
Authority:
United States: Federal Government
Study ID:
CDR0000540670
NCT ID:
NCT00467129
Start Date:
July 2002
Completion Date:
Related Keywords:
- Colorectal Cancer
- stage IV colon cancer
- stage IV rectal cancer
- Colorectal Neoplasms
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