Effect of Genistein on Endometrial Hyperplasia
Although isoflavones alone (example: Genistein) have weak estrogenic effects on endometrial
stromal and glandular cells, it was demonstrated, in several research efforts, that in the
presence of E2 they act as antiestrogens.
Considered that endometrial hyperplasia is due to strong and extended estrogenic
stimulation, not offset by a proportionate amount of progesterone, we suppose that genistein
could be therapeutic in these cases inducing a decrease of the hyperplasia and a change from
the proliferative to a secretory phase of the endometrium.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Recovery from endometrial hyperplasia
Rosario D'Anna, prof.
Italy: National Institute of Health
Roberta Granese, MD, PhD