Inclusion Criteria:

- Solid cancer for which curative measures have failed or for which there is no known
superior treatment

- ECOG performance status 0-2

- Measurable or non-measurable disease

- Life expectancy of greater than 12 weeks and no anticipated need for other
antineoplastic therapy in the next 4 weeks

- Age 18 years or older

- Patients must have adequate organ and marrow function as defined below:

- ALT and AST less than or equal to 2.5 x the ULN (< 5 x ULN for patients with
liver involvement).

- hemoglobin greater than or equal to 9 g/dL

- absolute neutrophil count greater than or equal to 1,500/μL

- platelets greater than or equal to 100,000/μL (greater than or equal to
35,000/μL without transfusion for patients with CLL/SLL or follicular lymphoma)

- total bilirubin less than or equal to 1.5 x ULN

- creatinine less than or equal to 1.5 x ULN

- Women of childbearing potential must have a negative pregnancy test within 7 days of
the start of treatment.

- Ability to understand and the willingness to sign a written informed consent document

- Must not have any evidence of bleeding diathesis.

Exclusion Criteria:

- Patients who have had chemotherapy or immunotherapy within 3 weeks or radiotherapy
within 14 days prior to entering the study

- Patients may not be receiving any other investigational agents or any concomitant
antineoplastic therapy

- Patients with uncontrolled brain metastases.

- Concurrent illness or medication exclusions

- HIV-positive patients receiving combination anti-retroviral therapy are excluded from
the study because of possible pharmacokinetic interactions with sorafenib or
rapamycin.