Inclusion Criteria:

- Pathological proof of clear cell carcinoma (or mixed tumors ≥ 75% clear cell
component)

- Evidence of measurable metastatic disease, no progression diseases or the patient's
condition will not need radiotherapy in the next 4 weeks.

- Previous definitive radiotherapy to 1 metastatic site is acceptable

- At least 4 weeks have elapsed since radiation therapy

- Patients must be free of serious co-morbidity and have a life expectancy of ≥24 weeks

- Patients should have adequate physiologic reserves as evidence of adequate
performance status, blood parameters, hepatic and kidney function, no evidence of
active cardiac diseases and showing an acceptable function and adequate coagulation
profile.

Exclusion Criteria:

- History of central nervous System metastases

- Known HIV positive

- Recent history of brain's vascular disease within 6 months; patients requiring
regular antianginal therapy (coronary disease) or insufficient circulation in lower
extremities are not eligible

- Active autoimmune disease

- Patients who have had steroid therapy in the past three weeks

- Patients taking concurrent anticancer drugs

- Biphosphonates (Zometa) are not allowed, unless started 4 weeks prior to
participation in the study

- Female patients pregnant or breast-feeding

- The patient has an unstable medical condition, such as uncontrolled Diabetes mellitus
or Hypertension; active infections requiring systemic antibiotics, antivirals, or
antifungal; clinical evidence of cardiac or pulmonary dysfunction including,
uncontrolled arrhythmias, unstable coagulation disorders; or recent myocardial
infarction (within 6 months)

- Any condition including abnormal laboratory results, that in the opinion of the
investigator places the patient at an unacceptable risk if he/she participate in the
study

- Prior malignancy (within the last 3 years), except for adequately treated basal cell
or squamous cell skin cancer, in situ cervical cancer or other cancer for which the
patient has been - free for at least 3 years

- Uncontrolled Blood pressure > 150/100

- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to Day 0, anticipation of need for major surgical procedure during the course
of the study

- Minor surgery 7 days before day 0

- Serious, non healing wound, ulcer, or bone fracture; and,inability to accomplish the
treatment