Trial Information

The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer

Sialadenitis and xerostomia are the most frequent adverse events of high-dose radioiodine
therapy. Saliva has vital functions in maintaining periodontal and oral health. Therefore,
xerostomia not only impairs quality of life permanently, but may also increase the risk of
caries and tooth extractions. Nevertheless, despite more than 6 decades of radioiodine
therapy for thyroid cancer, large studies on long-term oral adverse events are still
lacking. In the present study, we investigate the influence of high-dose radioiodine therapy
on the long-term oral health.