Dexamethasone for the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases
Of all people diagnosed with cancer, 25% will have their cancer come back and spread to the
bones. This often results in significant pain and suffering. Radiation treatment is often
recommended as a safe and quick treatment that gives most people good relief from bone pain
within a couple of weeks. However, some people can experience a short episode of increased
pain called a flare a day or two after radiation treatment that lasts about a day. Studies
suggest that around a third of all people who receive radiation treatment to help pain from
cancer in the bones will have a pain flare. This study is being done because it would be
helpful to prevent extra bone pain from happening to people after they receive radiation
treatments. The purpose of this study is to find out if a medication called dexamethasone
can help prevent pain flare as a result of radiation therapy.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Complete control of pain flare on days 1-5 after the completion of radiation treatment.
Edward Chow, MBBS PhD
Canada: Health Canada