Inclusion Criteria:

- adult patients, >=18 years of age;

- gastric cancer with unresectable locally advanced and/or metastatic disease;

- >=1 measurable lesion;

- ambulatory, with ECOG Performance Status >=1.

Exclusion Criteria:

- previous chemotherapy (except adjuvant or neoadjuvant treatment >=6 months prior to
enrollment);

- clinically significant cardiac disease or myocardial infarction within last 12
months;

- CNS metastases;

- history of other malignancy within last 5 years, except for cured basal cell cancer
of the skin, or in situ cancer of the cervix.