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Computer Assisted Early Detection of Liver Metastases From fMRI Maps

20 Years
Not Enrolling
Metastatic Colorectal Cancer

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Trial Information

Computer Assisted Early Detection of Liver Metastases From fMRI Maps

In this research, we propose to develop methods and protocols for imaging-based,
non-invasive early detection and diagnosis of colon cancer metastases. Colon cancer is the
third most common cancer worldwide. While it is amenable to surgery if detected early,
advanced carcinomas are usually lethal, with liver metastases being the most common cause of
death. Early and accurate detection of these lesions is recognized as having the potential
of improving survival rates and reducing treatment morbidity. Current diagnostic imaging
offers improved discrimination and sensitivity that can be used for earlier detection of
smaller lesions conducive to curative therapy.

In previous research, we demonstrated the feasibility of fMRI based on hypercapnia and
hyperoxia for monitoring changes in liver perfusion and hemodynamics without contrast agent
administration. The isolation and analysis of areas with significant hemodynamical changes
in images acquired at early phase of tumor development has proven to be a difficult, time
consuming, and potentially unreliable task. Our goal is thus two-fold: 1. use image
processing and machine learning tools on a training set of hemodynamical maps obtained from
well validated tumors to automate the process and improve its discrimination and sensitivity
characteristics, and; 2. implement our method in patients with colorectal liver metastases.
The method can help general radiologists with no image processing training to highlight
undetectable tumors from background noise and increase diagnosis specificity and

Inclusion Criteria:

- Control group of healthy volunteers

- Study group: Patients with colon cancer stage III or IV with high suspicion of liver
metastases: raising CEA, suspected lesion in the liver by CT or PET.

Exclusion Criteria:

- Contraindication to perform MRI.

Type of Study:


Study Design:

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal, Time Perspective: Prospective

Principal Investigator

Ayala Hubert, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Hadassah Medical Organization


Israel: Israeli Health Ministry Pharmaceutical Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Metastatic Colorectal Cancer
  • colon cancer
  • metastatic colorectal cancer
  • MRI
  • Magnetic resonance imaging
  • Early cancer detection
  • medical image processing
  • machine learning
  • disease modeling
  • Colon Cancer Stage III
  • Colorectal Neoplasms
  • Neoplasm Metastasis