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A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab or Placebo in Patients With Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Male Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer

Thank you

Trial Information

A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab or Placebo in Patients With Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer


PRIMARY OBJECTIVES:

I. Compare the disease-free survival (DFS) of patients with lymph node-positive or
high-risk, lymph node-negative breast cancer treated with adjuvant therapy comprising
doxorubicin hydrochloride, cyclophosphamide, and paclitaxel with vs. without bevacizumab.

SECONDARY OBJECTIVES:

I. Compare the overall survival of patients treated with these regimens. II. Determine the
toxicity of these regimens. III. Compare the efficacy of short-term (20-24 weeks) vs
long-term (50-54 weeks) bevacizumab, in terms of DFS, in these patients.

IV. Evaluate the association between outcomes (disease-free survival, overall survival and
toxicities) and genotype (derived from candidate single nucleotide polymorphisms and genome
wide evaluations).

V. Compare quality of life patients treated with these regimens, in terms of physical
symptoms, physical functioning, psychological state and social functioning over an 18 month
period. (QOL closed as of 05/28/10) VI. Determine the impact of theoretical biomarker
information on patients' willingness to accept the toxicities of bevacizumab for the
estimated potential benefit.

VII. Create a biospecimen repository including plasma, serum and CellSearch cassettes
containing circulating tumor cells (CTC) for evaluating determinants of late relapse,
including candidate biomarkers reflecting occult tumor burden (e.g., CTCs and plasma tumor
DNA) and host factors (e.g., estrogen, insulin-IGF axis, inflammation, etc).

VIII. Create a biorepository of metastatic tumor samples in patients who have had a late
relapse.

XV. Determine body mass index (BMI) and comorbidity burden in patients with operable breast
cancer five or more years after diagnosis.

X. Determine whether there is a relationship between late relapse and BMI at diagnosis and
at 5 years after diagnosis, and whether BMI-associated inflammatory and/or metabolic
biomarkers are associated with early and late recurrence.

OUTLINE: This is a randomized, partially double-blind, placebo-controlled, partially
open-label, multicenter study. Patients are stratified according to planned dose schedule of
doxorubicin hydrochloride and cyclophosphamide (every 3 weeks vs every 2 weeks). Patients
are further stratified according to estrogen receptor status (positive vs negative), lymph
node involvement (node-negative vs 1-3 positive node[s] vs ≥ 4 positive nodes), and
received/planned treatment (lumpectomy and whole breast radiation therapy vs lumpectomy and
accelerated partial-breast radiation therapy [before or after chemotherapy] vs mastectomy
without radiation therapy vs mastectomy [with local or regional]). Patients are randomized
to 1 of 3 treatment arms (20% of patients are randomized to Arm I, 40% to Arm II, and 40% to
Arm III).

ARM I: Patients receive doxorubicin hydrochloride IV, cyclophosphamide IV over 20-30
minutes, and placebo IV over 30-90 minutes on day 1. Treatment repeats every 2 or 3 weeks
for 4 courses. Beginning 3 weeks later, patients then receive paclitaxel IV over 1 hour on
days 1, 8, and 15 and placebo IV over 30-90 minutes on day 1. Treatment with paclitaxel and
placebo repeats every 3 weeks for 4 courses.

ARM II: Patients receive doxorubicin hydrochloride and cyclophosphamide as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 or 3 weeks for 4
courses. Beginning 3 weeks later, patients then receive paclitaxel as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment with paclitaxel and bevacizumab
repeats every 3 weeks for 4 courses.

ARM III: Patients receive doxorubicin hydrochloride and cyclophosphamide as in arm I and
bevacizumab as in arm II. Treatment repeats every 2 or 3 weeks for 4 courses. Beginning 3
weeks later, patients then receive paclitaxel as in arm I and bevacizumab as in arm II.
Treatment with paclitaxel and bevacizumab repeats every 3 weeks for 4 courses. Beginning 2
months later, patients then receive open-label bevacizumab IV over 30-90 minutes on day 1.
Treatment with bevacizumab alone repeats every 3 weeks for 10 courses.

In all arms, treatment continues in the absence of disease progression or unacceptable
toxicity. Patients complete quality of life (QOL) questionnaires followed by telephone QOL
interviews at baseline and periodically. (QOL closed as of 05/28/10)

After completion of study treatment, patients are followed periodically for up to 15 years.


Inclusion Criteria:



- Histologically confirmed adenocarcinoma of the breast at significant risk of distant
recurrence based on at least one of the following criteria:

- Involvement of at least one sentinel or axillary lymph node on routine
histologic examination; patients with negative sentinel nodes and negative
axillary nodes or involvement only demonstrated by immunohistochemistry are not
eligible unless they meet one of the other eligibility criteria below

- Estrogen receptor (ER) negative tumor >= 1 cm

- ER+ tumor >= 5 cm regardless of recurrence score

- ER+ tumor >= 1 cm but < 5 cm with a recurrence score >= 11; (patients enrolled
in the TAILORx trial are eligible)

- Patients must have completed definitive breast surgery including total mastectomy and
axillary dissection (modified radical mastectomy), total mastectomy and sentinel node
biopsy, breast conservation surgery and axillary dissection or breast conservation
surgery and sentinel node biopsy

- Planned post-lumpectomy radiation therapy required, including any of the following:

- Whole breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy prior to chemotherapy

- Margins of breast conservation surgery or mastectomy must be histologically free of
invasive breast cancer and ductal carcinoma in situ (DCIS); patients with resection
margins positive for lobular carcinoma in situ (LCIS) are eligible

- Time from last surgery for breast cancer (breast conservation surgery, mastectomy,
sentinel node biopsy, axillary dissection or re-excision of breast conservation
surgery margins) to planned treatment start date must be > 28 days and =< 84 days

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- Absolute neutrophil count >= 1,000/mm^3

- Platelet count >= 100,000/mm^3

- Bilirubin =< 1.5 mg/dL

- Aspartate transferase (AST) =< 2 times upper limit of normal(ULN)

- Creatinine =< 1.5 mg/dL

- Urine protein:creatinine ratio < 1.0 or 24-hour protein

- Partial thromboplastin time (PTT) =< 1.5 times ULN

- Left ventricle ejection fraction (LVEF) normal by echocardiogram (ECHO) or multigated
acquisition scan (MUGA)

- Patients who have undergone breast conservation surgery must receive radiation; prior
to randomization, the investigator must specify the planned radiation technique:

- Whole breast radiation (WBRT) after chemotherapy

- Accelerated partial breast radiation (APBI) after chemotherapy

- Accelerated partial breast radiation (APBI) prior to chemotherapy

- Post-mastectomy radiation therapy (RT) is required for all patients with a primary
tumor of >= 5 cm or involvement of 4 or more lymph nodes; post-mastectomy RT may be
administered at the investigator's discretion for all other mastectomy patients

- Patients with human epidermal growth factor receptor (HER)2 + (3+ by
immunohistochemistry [IHC] or fluorescent in situ hybridisation [FISH] ratio >= 2)
breast cancer are not eligible

- Patients with synchronous bilateral breast cancer (diagnosed =< 1 month) if the
higher TNM stage tumor meets the eligibility criteria for this trial

- Patients must not have clinical evidence of inflammatory disease or fixed axillary
nodes at diagnosis

- Patients must not have received prior cytotoxic chemotherapy or hormonal therapy for
this breast cancer; prior treatment with an anthracycline, anthracenedione or taxane
for any condition is not allowed

- Patients must not have had any major surgical procedure within 28 days of planned
treatment start date

- Patients may not have had placement of a vascular access device within 24 hours of
planned Day 1 of treatment

- Patients must not have clinically significant cardiovascular or cerebrovascular
disease, including:

Any history of

- Cerebrovascular disease including transient ischemic attack (TIA), stroke or
subarachnoid hemorrhage

- Ischemic bowel within the last 12 months

- Myocardial infarction

- Unstable angina

- New York Heart Association (NYHA) class II or greater congestive heart failure

- Grade II or greater peripheral vascular disease

- Uncontrolled hypertension defined as systolic blood pressure (SBP) > 160 or diastolic
blood pressure (DBP) > 90

- Uncontrolled or clinically significant arrhythmia

- Patients who require full-dose anticoagulation may enroll provided they meet the
following criteria:

- The patient must have an in-range International Normalized Ratio (INR) (usually
between 2 and 3) on a stable dose of warfarin or be on stable dose of low molecular
weight (LMW) heparin

- The patient must not have active bleeding or pathological conditions that carry high
risk of bleeding (e.g. varices)

- Patients must not have a bleeding diathesis, hereditary or acquired bleeding
disorder or coagulopathy

- Patients must not have a non-healing wound or fracture; patients with an
abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
within 6 months prior to randomization are not eligible

- Patients must not have hypersensitivity to paclitaxel or drugs using the vehicle
Cremophor, Chinese hamster ovary cell products or other recombinant human
antibodies

- Women must not be pregnant or breast-feeding due to the potential harmful
effects of bevacizumab on the developing fetus; all females of childbearing
potential must have a blood or urine test within 7 days prior to randomization
to rule out pregnancy

- Women of childbearing potential and sexually active males must use an accepted
and effective method of contraception

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free survival (DFS)

Outcome Time Frame:

From the date of randomization to the date of first treatment failure, assessed up to 15 years

Safety Issue:

No

Principal Investigator

Kathy Miller

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2009-00561

NCT ID:

NCT00433511

Start Date:

November 2007

Completion Date:

Related Keywords:

  • Male Breast Cancer
  • Stage IA Breast Cancer
  • Stage IB Breast Cancer
  • Stage II Breast Cancer
  • Stage IIIA Breast Cancer
  • Stage IIIB Breast Cancer
  • Breast Neoplasms
  • Breast Neoplasms, Male

Name

Location

Albert Einstein College of MedicineBronx, New York  10461
Baylor College of MedicineHouston, Texas  77030
Howard University HospitalWashington, District of Columbia  20060
Johns Hopkins UniversityBaltimore, Maryland  21205
Suburban HospitalBethesda, Maryland  20814
Memorial Sloan Kettering Cancer CenterNew York, New York  10021
Roswell Park Cancer InstituteBuffalo, New York  14263
Mayo ClinicRochester, Minnesota  55905
George Washington University Medical CenterWashington, District of Columbia  20037
Washington University School of MedicineSaint Louis, Missouri  63110
Abington Memorial HospitalAbington, Pennsylvania  19001
Fox Chase Cancer CenterPhiladelphia, Pennsylvania  19111
Medical University of South CarolinaCharleston, South Carolina  29425-0721
Hurley Medical CenterFlint, Michigan  48503
Rhode Island HospitalProvidence, Rhode Island  02903
Medical City Dallas HospitalDallas, Texas  75230
Pennsylvania HospitalPhiladelphia, Pennsylvania  19107
Beth Israel Deaconess Medical CenterBoston, Massachusetts  02215
Boulder Community HospitalBoulder, Colorado  80301-9019
Porter Adventist HospitalDenver, Colorado  80210
Rose Medical CenterDenver, Colorado  80220
Swedish Medical CenterEnglewood, Colorado  80110
Sky Ridge Medical CenterLone Tree, Colorado  80124
North Suburban Medical CenterThornton, Colorado  80229
Bronson Methodist HospitalKalamazoo, Michigan  49007
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Borgess Medical CenterKalamazooaa, Michigan  49001
Fairview Ridges HospitalBurnsville, Minnesota  55337
Hutchinson Area Health CareHutchinson, Minnesota  55350
Meeker County Memorial HospitalLichfield, Minnesota  55355
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, Pennsylvania  19104-4283
Avera Cancer InstituteSioux Falls, South Dakota  57105
Loyola University Medical CenterMaywood, Illinois  60153
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
CentraCare ClinicSaint Cloud, Minnesota  56303
Rapid City Regional HospitalRapid City, South Dakota  57709
Morristown Memorial HospitalMorristown, New Jersey  07962-1956
Marshfield ClinicMarshfield, Wisconsin  54449
Glendale Memorial Hospital and Health CenterGlendale, California  91204
Sutter Health Western Division Cancer Research GroupGreenbrae, California  94904
Ingalls Memorial HospitalHarvey, Illinois  60426
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Mary Bird Perkins Cancer CenterBaton Rouge, Louisiana  70809
Cape Cod HospitalHyannis, Massachusetts  02601
Newark Beth Israel Medical CenterNewark, New Jersey  07112
Beth Israel Medical CenterNew York, New York  10003
Champlain Valley Physicians Hospital Medical CenterPlattsburgh, New York  12901
Akron General Medical CenterAkron, Ohio  44302
Lehigh Valley HospitalAllentown, Pennsylvania  18103
Delaware County Memorial HospitalDrexel Hill, Pennsylvania  19026
Reading Hospital and Medical CenterReading, Pennsylvania  19612-6052
Grand View HospitalSellersville, Pennsylvania  18960
York HospitalYork, Pennsylvania  17315
Waukesha Memorial HospitalWaukesha, Wisconsin  53188
Rush University Medical CenterChicago, Illinois  60612-3824
Virginia Piper Cancer InstituteMinneapolis, Minnesota  55407
University of Arkansas for Medical SciencesLittle Rock, Arkansas  72205
University of Kansas Medical CenterKansas City, Kansas  66160-7353
Boston Medical CenterBoston, Massachusetts  02118
Brooke Army Medical CenterFort Sam Houston, Texas  78234-6200
Eastern Maine Medical CenterBangor, Maine  04401
Franklin Square Hospital CenterBaltimore, Maryland  21237
Baystate Medical CenterSpringfield, Massachusetts  01199
Staten Island University HospitalStaten Island, New York  10305
Camden-Clark Memorial HospitalParkersburg, West Virginia  26102
Providence Alaska Medical CenterAnchorage, Alaska  99508
William Beaumont HospitalRoyal Oak, Michigan  48073
Cancer Institute of New JerseyNew Brunswick, New Jersey  08901
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, California  95051-5386
Broward General Medical CenterFort Lauderdale, Florida  33316
Via Christi Regional Medical CenterWichita, Kansas  67214
Ochsner Clinic FoundationNew Orleans, Louisiana  70121
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73104
Legacy Emanuel Hospital and Health CenterPortland, Oregon  97227
Scott and White Memorial HospitalTemple, Texas  76508
Northeast Alabama Regional Medical CenterAnniston, Alabama  36207
Saint Anthony Medical CenterRockford, Illinois  61108
Iowa Methodist Medical CenterDes Moines, Iowa  50309
Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Elmhurst Hospital CenterElmhurst, New York  11373
Weill Medical College of Cornell UniversityNew York, New York  10021
Medical Center of Central GeorgiaMacon, Georgia  31201
Maimonides Medical CenterBrooklyn, New York  11219
University of Wisconsin Hospital and ClinicsMadison, Wisconsin  53792-0001
Great Falls ClinicGreat Falls, Montana  59405
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Overlook HospitalSummit, New Jersey  07902-0220
Cancer Institute of New Jersey at HamiltonHamilton, New Jersey  08690
MetroHealth Medical CenterCleveland, Ohio  44109
Valley HospitalRidgewood, New Jersey  07450
Vassar Brothers Medical CenterPoughkeepsie, New York  12601
Trinity Cancer Care CenterMinot, North Dakota  58701
Mercy Fitzgerald HospitalDarby, Pennsylvania  19023
Wilford Hall Medical CenterLackland Air Force Base, Texas  78236-5300
Eisenhower Medical CenterRancho Mirage, California  92270
Advocate Christ Medical CenterOak Lawn, Illinois  60453
Mount Sinai Medical CenterNew York, New York  10029
Montefiore Medical CenterBronx, New York  10467-2490
Saint Peter's University HospitalNew Brunswick, New Jersey  08901-1780
Lewistown HospitalLewistown, Pennsylvania  17044
Mount Nittany Medical CenterState College, Pennsylvania  16803
Sibley Memorial HospitalWashington, District of Columbia  20016
North Colorado Medical CenterGreeley, Colorado  80631
McKee Medical CenterLoveland, Colorado  80539
Cancer Center of Kansas - ChanuteChanute, Kansas  66720
Cancer Center of Kansas - Dodge CityDodge City, Kansas  67801
Cancer Center of Kansas - NewtonNewton, Kansas  67114
Cancer Center of Kansas - SalinaSalina, Kansas  67042
Cancer Center of Kansas - WellingtonWellington, Kansas  67152
Associates in Womens HealthWichita, Kansas  67203
Cancer Center of Kansas - WinfieldWinfield, Kansas  67156
Holland Community HospitalHolland, Michigan  49423
Munson Medical CenterTraverse City, Michigan  49684
Northern Rockies Radiation Oncology CenterBillings, Montana  59101
Bozeman Deaconess HospitalBozeman, Montana  59715
Kalispell Medical OncologyKalispell, Montana  59901
Kalispell Regional Medical CenterKalispell, Montana  59901
Adena Regional Medical CenterChillicothe, Ohio  54601
Grady Memorial HospitalDelaware, Ohio  43015
Fairfield Medical CenterLancaster, Ohio  43130
Avera McKennan Hospital and University Health CenterSioux Falls, South Dakota  57105
Medical X-Ray CenterSioux Falls, South Dakota  57105
Welch Cancer CenterSheridan, Wyoming  82801
University of New Mexico Cancer CenterAlbuquerque, New Mexico  87131-5636
Brigham and Women's HospitalBoston, Massachusetts  02115
Methodist Estabrook Cancer CenterOmaha, Nebraska  68114-4199
Mercy Health SystemJanesville, Wisconsin  53545
Paoli Memorial HospitalPaoli, Pennsylvania  19301-1792
Elkhart General HospitalElkhart, Indiana  46515
South Bend ClinicSouth Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, Ohio  43210-1240
Parkland Memorial HospitalDallas, Texas  75235
Front Range Cancer SpecialistsFort Collins, Colorado  80528
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Finger Lakes Hematology and OncologyClifton Springs, New York  14432
Jennersville Regional HospitalWest Grove, Pennsylvania  19390-9499
Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Sutter Solano Medical CenterVallejo, California  94589
Poudre Valley HospitalFort Collins, Colorado  80524
Beebe Medical CenterLewes, Delaware  19958
Saint Joseph's Hospital of AtlantaAtlanta, Georgia  30342-1701
Piedmont HospitalAtlanta, Georgia  30309
Gwinnett Medical CenterLawrenceville, Georgia  30045
Southern Regional Medical CenterRiverdale, Georgia  30274-2600
Memorial HospitalCarthage, Illinois  62321
Swedish Covenant HospitalChicago, Illinois  60625
Hematology and Oncology AssociatesChicago, Illinois  60611
Galesburg Cottage HospitalGalesburg, Illinois  61401
Galesburg ClinicGalesburg, Illinois  61401
Mason District HospitalHavana, Illinois  62644
McDonough District HospitalMacomb, Illinois  61455
BroMenn Regional Medical CenterNormal, Illinois  61761
Proctor HospitalPeoria, Illinois  61614
Perry Memorial HospitalPrinceton, Illinois  61356
Genesis Medical Center - West CampusDavenport, Iowa  52804
Salina Regional Health CenterSalina, Kansas  67401
Mecosta County Medical CenterBig Rapids, Michigan  49307
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Bismarck Cancer CenterBismarck, North Dakota  58501
Grandview HospitalDayton, Ohio  45405
Mercy Medical CenterSpringfield, Ohio  45504
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Legacy Meridian Park HospitalTualatin, Oregon  97062
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
Mountainview MedicalBerlin, Vermont  05602
North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, Washington  98902
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
Eureka HospitalEureka, Illinois  61530
Mercy HospitalCoon Rapids, Minnesota  55433
Allenmore HospitalTacoma, Washington  98411-0414
Graham Hospital AssociationCanton, Illinois  61520
Holy Family Medical CenterDes Plaines, Illinois  60016
Hematology Oncology Associates of Illinois-Highland ParkHighland Park, Illinois  60035
Saint Joseph Medical CenterJoliet, Illinois  60435
Pekin HospitalPekin, Illinois  61554
Medical Oncology and Hematology AssociatesDes Moines, Iowa  50309
Ottumwa Regional Health CenterOttumwa, Iowa  52501
Anne Arundel Medical CenterAnnapolis, Maryland  21401
Saint Joseph Mercy HospitalAnn Arbor, Michigan  48106
Fairview-Southdale HospitalEdina, Minnesota  55435
Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Regional Medical CenterShakopee, Minnesota  55379
Rice Memorial HospitalWillmar, Minnesota  56201
Mary Imogene Bassett HospitalCooperstown, New York  13326
Altru Cancer CenterGrand Forks, North Dakota  58206
Lancaster General HospitalLancaster, Pennsylvania  17604-3555
Geisinger Medical GroupState College, Pennsylvania  16801
Fox Valley Hematology and OncologyAppleton, Wisconsin  54911
Alaska Regional HospitalAnchorage, Alaska  99508
Highland General HospitalOakland, California  94602
Pomona Valley Hospital Medical CenterPomona, California  91767
Northeast Georgia Medical CenterGainesville, Georgia  30501
Swedish American HospitalRockford, Illinois  61104
Central Maine Medical CenterLewiston, Maine  04240
Saint Luke's HospitalChesterfield, Missouri  63017
Center for Cancer Care and ResearchSt. Louis, Missouri  63141
Randolph HospitalAsheboro, North Carolina  27203
Miami Valley HospitalDayton, Ohio  45409
Allegheny Cancer Center at Allegheny General HospitalPittsburgh, Pennsylvania  15212
Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Cancer Center of Kansas - Fort ScottFort Scott, Kansas  66701
Cancer Center of Kansas-IndependenceIndependence, Kansas  67301
Lawrence Memorial HospitalLawrence, Kansas  66044
Bozeman Deaconess Cancer CenterBozeman, Montana  59715
Northern Montana HospitalHavre, Montana  59501
Mary Rutan HospitalBellefontaine, Ohio  43311
Wayne HospitalGreenville, Ohio  45331
Knox Community HospitalMount Vernon, Ohio  43050
Clinton Memorial HospitalWilmington, Ohio  45177
Adventist Medical CenterPortland, Oregon  97216
Providence Centralia HospitalCentralia, Washington  98531-9027
Marshfield Clinic Cancer Care at Regional Cancer CenterEau Claire, Wisconsin  54701
UW Cancer Center Johnson CreekJohnson Creek, Wisconsin  53038
Saint Joseph's HospitalMarshfield, Wisconsin  54449
Marshfield Clinic - Weston CenterWeston, Wisconsin  54476
Diagnostic and Treatment CenterWeston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, Wisconsin  54494
Rocky Mountain OncologyCasper, Wyoming  82609
Longmont United HospitalLongmont, Colorado  80501
Lincoln Medical and Mental Health CenterBronx, New York  10451
Baton Rouge General Medical CenterBaton Rouge, Louisiana  70821-2511
Zale Lipshy University HospitalDallas, Texas  75235-7786
Aurora Sinai Medical CenterMilwaukee, Wisconsin  53201-0342
Sharp Memorial HospitalSan Diego, California  92123
Greene Memorial HospitalXenia, Ohio  45385
Easton HospitalEaston, Pennsylvania  18042
Greater Baltimore Medical CenterBaltimore, Maryland  21204
Lowell General HospitalLowell, Massachusetts  01854
Rutherford HospitalRutherfordton, North Carolina  28139
Three Rivers Community HospitalGrants Pass, Oregon  97527
Providence Medford Medical CenterMedford, Oregon  97504
Harold Alfond Center for Cancer CareAugusta, Maine  04330
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Miriam HospitalProvidence, Rhode Island  02906
Presbyterian HospitalCharlotte, North Carolina  28233-3549
Mayo Clinic in ArizonaScottsdale, Arizona  85259-5404
Mayo Clinic in FloridaJacksonville, Florida  32224
Washington Hospital CenterWashington, District of Columbia  20010
Memorial Medical CenterSpringfield, Illinois  62781
Englewood Hospital and Medical CenterEnglewood, New Jersey  07631
Southeastern Medical Oncology CenterGoldsboro, North Carolina  27534
Doylestown HospitalDoylestown, Pennsylvania  18901
McLeod Regional Medical CenterFlorence, South Carolina  29501
Wellmont Holston Valley Hospital and Medical CenterKingsport, Tennessee  37662
La Grange Memorial HospitalLa Grange, Illinois  60525
Metro Health HospitalGrand Rapids, Michigan  49506
Guardian Oncology and Center for WellnessMissoula, Montana  59804
Queen's Medical CenterHonolulu, Hawaii  96813
University of VirginiaCharlottesville, Virginia  22908
University of PittsburghPittsburgh, Pennsylvania  15261
Woodwinds Health CampusWoodbury, Minnesota  55125
University of Alabama at BirminghamBirmingham, Alabama  35294-3300
Providence HospitalMobile, Alabama  36608
Vanderbilt UniversityNashville, Tennessee  37232-6305
University of North CarolinaChapel Hill, North Carolina  27599
Meharry Medical CollegeNashville, Tennessee  37208-3599
Good Samaritan Hospital of MarylandBaltimore, Maryland  21239
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Northwestern UniversityChicago, Illinois  60611
Cancer Care AssociatesTulsa, Oklahoma  74136
East Bay Radiation Oncology CenterCastro Valley, California  94546
Contra Costa Regional Medical CenterMartinez, California  94553-3156
Larry G Strieff MD Medical CorporationOakland, California  94609
Tahoe Forest Cancer CenterTruckee, California  96161
Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
Kapiolani Medical Center for Women and ChildrenHonolulu, Hawaii  96826
Maui Memorial Medical CenterWailuku, Hawaii  96793
Elmhurst Memorial HospitalElmhurst, Illinois  60126
Bay Area HospitalCoos Bay, Oregon  97420
Hennepin County Medical CenterMinneapolis, Minnesota  
Queens Hospital CenterJamaica, New York  11432
University of RochesterRochester, New York  14642
Saint Alphonsus Regional Medical CenterBoise, Idaho  83706
Holy Cross HospitalFort Lauderdale, Florida  33308
El Camino HospitalMountain View, California  94040
Cleveland Clinic Florida - WestonWeston, Florida  33331
University of California at San DiegoLa Jolla, California  92093
Case Western Reserve UniversityCleveland, Ohio  44106
Emory UniversityAtlanta, Georgia  30322
Wayne State UniversityDetroit, Michigan  48202
New Hampshire Oncology-Hematology PAHooksett, New Hampshire  03106
Albert Einstein Medical CenterPhiladelphia, Pennsylvania  19141
Straub Clinic and HospitalHonolulu, Hawaii  96813
Lakeland Regional Cancer CenterLakeland, Florida  33805
Riverside Methodist HospitalColumbus, Ohio  43214
Licking Memorial HospitalNewark, Ohio  43055-2899
Providence Portland Medical CenterPortland, Oregon  97213-3635
California Pacific Medical CenterSan Francisco, California  94115
Mid Dakota ClinicBismarck, North Dakota  58501
Columbus CCOPColumbus, Ohio  43206
Indiana University Medical CenterIndianapolis, Indiana  46202
Weiss Memorial HospitalChicago,, Illinois  60640
University Of VermontBurlington,, Vermont  05403
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado  80218
Kaiser PermanenteSacramento, California  
University of Texas Southwestern Medical CenterDallas, Texas  
Wichita CCOPWichita, Kansas  67214-3882
Montana Cancer Consortium CCOPBillings, Montana  59101
Alegent Health Immanuel Medical CenterOmaha, Nebraska  68122
Alegent Health Bergan Mercy Medical CenterOmaha, Nebraska  68124
Huntsman Cancer Institute/University of UtahSalt Lake City, Utah  84112
Mount Sinai Hospital Medical CenterChicago, Illinois  60608
Addison Gilbert HospitalGloucester, Massachusetts  01930
Columbia Saint Mary's Hospital - OzaukeeMequon, Wisconsin  53097
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
UC Davis Comprehensive Cancer CenterSacramento, California  95817
Providence HospitalSouthfield, Michigan  48075
Tufts Medical CenterBoston, Massachusetts  02111
Oregon Health and Science UniversityPortland, Oregon  97201
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania  19131
Jersey Shore Medical CenterNeptune, New Jersey  07754
Decatur Memorial HospitalDecatur, Illinois  62526
Louisiana State University Health Science CenterNew Orleans, Louisiana  70112
Kaiser PermanentePortland, Oregon  97227
Frederick Memorial HospitalFrederick, Maryland  21701
Lankenau HospitalWynnewood, Pennsylvania  19096
Princeton Community HospitalPrinceton, West Virginia  24740
Montana Cancer SpecialistsMissoula, Montana  59807-7877
Desert Regional Medical CenterPalm Springs, California  92262
Boca Raton Comprehensive Cancer CenterBoca Raton, Florida  33486
Providence Saint Joseph Medical CenterBurbank, California  91505-4866
Florida HospitalOrlando, Florida  32803
Memorial Health University Medical CenterSavannah, Georgia  31404
Phoenixville HospitalPhoenixville, Pennsylvania  19460
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
University of Southern CaliforniaLos Angeles, California  90033
DeKalb Medical CenterDecatur, Georgia  30033
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
Hawaii Medical Center EastHonolulu, Hawaii  96817
Norwalk HospitalNorwalk, Connecticut  06856
Vince Lombardi Cancer Clinic - OshkoshOshkosh, Wisconsin  54904
Penn State Milton S Hershey Medical CenterHershey, Pennsylvania  17033
Hematology Oncology AssociatesAlbuquerque, New Mexico  87106
The Community HospitalMunster, Indiana  46321
North Broward Medical CenterDearfield Beach, Florida  33064-3596
Wake Forest University Health SciencesWinston-Salem, North Carolina  27157
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Northside HospitalAtlanta, Georgia  30342
Saint Helena HospitalSaint Helena, California  94574
Saint Edward Mercy Medical CenterFt. Smith, Arkansas  72903
Mills - Peninsula HospitalsBurlingame, California  94010
Valley Medical Oncology Consultants-Castro ValleyCastro Valley, California  94546
Eden Hospital Medical CenterCastro Valley, California  94546
Valley Medical Oncology Consultants-FremontFremont, California  94538
Kaiser Permanente, FremontFremont, California  94538
Kaiser Permanente, HaywardHayward, California  94545
Fremont - Rideout Cancer CenterMarysville, California  95901
Community Hospital of Monterey PeninsulaMonterey, California  93940
Palo Alto Medical Foundation-Camino DivisionMountain View, California  94040
Bay Area Breast Surgeons IncOakland, California  94609
Bay Area Tumor Institution CCOPOakland, California  94609
Tom K Lee IncOakland, California  94609
Kaiser Permanente-OaklandOakland, California  94611
Palo Alto Medical Foundation Heath CarePalo Alto, California  94301
Valley Medical Oncology ConsultantsPleasanton, California  94588
Valley Care Health System - PleasantonPleasanton, California  94588
Kaiser Permanente-Redwood CityRedwood City, California  94063
Kaiser Permanente-RichmondRichmond, California  94801
Kaiser Permanente-RosevilleRoseville, California  95661
Kaiser Permanente-South SacramentoSacramento, California  95823
Kaiser Permanente - SacramentoSacramento, California  95825
Kaiser Permanente-San FranciscoSan Francisco, California  94115
University of California San Francisco Medical Center-Mount ZionSan Francisco, California  94115
Kaiser Permanente-Santa Teresa-San JoseSan Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer CenterSan Pablo, California  94806
Kaiser Permanente-San RafaelSan Rafael, California  94903
Kaiser Permanente-Santa RosaSanta Rosa, California  95403
Kaiser Permanente-South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Memorial Hospital Colorado SpringsColorado Springs, Colorado  80909
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
Danbury HospitalDanbury, Connecticut  06810
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
Middlesex HospitalMiddletown, Connecticut  06457
The Hospital of Central ConnecticutNew Britain, Connecticut  06050
Stamford HospitalStamford, Connecticut  06904
Bayhealth Medical Center at Kent GeneralDover, Delaware  19901
Lombardi Comprehensive Cancer Center at Georgetown UniversityWashington, District of Columbia  20057
The Watson ClinicLakeland, Florida  33805
Cancer Centers of Central Florida PALeesburg, Florida  34788
Atlanta Regional CCOPAtlanta, Georgia  30342
Well Star Cobb HospitalAustell, Georgia  30106
John B Amos Cancer CenterColumbus, Georgia  31904
Wellstar Kennestone HospitalMarietta, Georgia  30060
Saint Joseph's-Candler Health SystemSavannah, Georgia  31405
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Pacific Cancer Institute of MauiWailuku, Hawaii  96793
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
Saint Anthony's HealthAlton, Illinois  62002
Rush - Copley Medical CenterAurora, Illinois  60504
Resurrection HealthcareChicago, Illinois  60631
Cancer Institute at Alexian BrothersElk Grove Village, Illinois  60007
Saint Francis HospitalEvanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystemEvanston, Illinois  60201
Hopedale Medical Complex - HospitalHopedale, Illinois  61747
Joliet Oncology-Hematology Associates LimitedJoliet, Illinois  60435
Midwest Center for Hematology OncologyJoliet, Illinois  60432
Provena Saint Mary's HospitalKankakee, Illinois  60901
North Shore Hematology OncologyLibertyville, Illinois  60048
Stoffel, Thomas J MD (UIA Investigator)Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator)Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator)Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator)Moline, Illinois  61265
Good Samaritan Regional Medical CenterMt. Vernon, Illinois  62864
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
West Suburban Cancer CenterRiver Forest, Illinois  60305
Hematology Oncology Associates of Illinois - SkokieSkokie, Illinois  60076
Edward H Kaplan MD and AssociatesSkokie, Illinois  60076
Saint Margaret's HospitalSpring Valley, Illinois  61362
Carle Clinic-Urbana MainUrbana, Illinois  61801
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State BoulevardFort Wayne, Indiana  46845
Wishard HospitalIndianapolis, Indiana  46202
Saint Vincent Hospital and Health ServicesIndianapolis, Indiana  46260
Premier Oncology Hematology AssociatesMerrillville, Indiana  46410
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
McFarland ClinicAmes, Iowa  50010
Hematology Oncology Associates-Quad CitiesBettendorf, Iowa  52722
Constantinou, Costas L MD (UIA Investigator)Bettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLCCedar Rapids, Iowa  52402
Mercy HospitalCedar Rapids, Iowa  52403
Saint Luke's HospitalCedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Genesis Medical Center - East CampusDavenport, Iowa  52803
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy CapitolDes Moines, Iowa  50307
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center - North IowaMason City, Iowa  50401
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Covenant Medical CenterWaterloo, Iowa  50702
Cancer Center of Kansas - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas-KingmanKingman, Kansas  67068
Cancer Center of Kansas - ParsonsParsons, Kansas  67357
Cancer Center of Kansas - PrattPratt, Kansas  67124
Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Saint Francis Hospital and Medical Center - TopekaTopeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas - Main OfficeWichita, Kansas  67214
Ochsner Clinic Foundation-Baton RougeBaton Rouge, Louisiana  70809
Medical Center of LouisianaNew Orleans, Louisiana  70112
The Union Memorial HospitalBaltimore, Maryland  21218
Associates in Oncology Hematology PC -KensingtonKensington, Maryland  20895
Associates In Oncology Hematology PC-RockvilleRockville, Maryland  20878
Caritas Saint Elizabeth's Medical CenterBrighton, Massachusetts  02135-2997
Norwood HospitalNorwood, Massachusetts  02062
Berkshire Hematology Oncology PCPittsfield, Massachusetts  01201
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mid-Michigan Medical Center - MidlandMidland, Michigan  48670
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Mercy Health Partners-Hackley CampusMuskegon, Michigan  49442
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Medini, Eitan MD (UIA Investigator)Alexandria, Minnesota  56308
Miller-Dwan HospitalDuluth, Minnesota  55805
Saint Luke's Hospital of DuluthDuluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator)Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator)Fergus Falls, Minnesota  56537
Unity HospitalFridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health SystemMankato, Minnesota  56002
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Saint Joseph's Hospital - HealtheastSaint Paul, Minnesota  55102
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Keesler Medical CenterKessler AFB, Mississippi  39534
Southeast Missouri HospitalCape Girardeau, Missouri  63701
Saint John's Regional Medical CenterJoplin, Missouri  64804
Freeman Health SystemJoplin, Missouri  64804
Missouri Cancer Care PC - Saint CharlesSaint Charles, Missouri  63301
Saint Louis-Cape Girardeau CCOPSaint Louis, Missouri  63141
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Saint John's Mercy Medical CenterSaint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator)Great Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Community Medical HospitalMissoula, Montana  59801
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Nevada Cancer Research Foundation CCOPLas Vegas, Nevada  89106
Exeter HospitalExeter, New Hampshire  03833
New Hampshire Oncology Hematology AssociatesHooksett, New Hampshire  03106
Cheshire Medical Center-Dartmouth-Hitchcock KeeneKeene, New Hampshire  03431
LRGHealthcare-Lakes Region General HospitalLaconia, New Hampshire  03246
Ocean Medical CenterBrick, New Jersey  08724
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Hunterdon Medical CenterFlemington, New Jersey  08822
Saint Barnabas Medical CenterLivingston, New Jersey  07039
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
Sparta Cancer Treatment CenterSparta, New Jersey  07871
South Jersey HealthcareVineland, New Jersey  08360
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
Presbyterian Kaseman HospitalAlbuquerque, New Mexico  87110
Memorial Medical Center - Las CrucesLas Cruces, New Mexico  88011
Orange Regional Medical CenterMiddletown, New York  10940
New York University Langone Medical CenterNew York, New York  10016
Saint Luke's Roosevelt Hospital Center - Saint Luke's DivisionNew York, New York  10025
Columbia University Medical CenterNew York, New York  10032
Interlakes Foundation Inc-RochesterRochester, New York  14623
Highland HospitalRochester, New York  14620
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Faxton-Saint Luke's HealthcareUtica, New York  13502
Mission Hospitals IncAsheville, North Carolina  28801
Alamance Regional Medical CenterBurlington, North Carolina  27216
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Margaret R Pardee Memorial HospitalHendersonville, North Carolina  28791
Kinston Medical Specialists PAKinston, North Carolina  28501
Marion L Shepard Cancer CenterWashington, North Carolina  27889
Saint Alexius Medical CenterBismarck, North Dakota  58501
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Veteran Affairs Medical CenterDayton, Ohio  45428
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Marietta Memorial HospitalMarietta, Ohio  45750
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Wright-Patterson Medical CenterWright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare SystemZanesville, Ohio  43701
Natalie W Bryant Cancer CenterTulsa, Oklahoma  74136
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer CenterPortland, Oregon  97227
Providence Saint Vincent Medical CenterPortland, Oregon  97225
Columbia River Oncology ProgramPortland, Oregon  97225
Salem HospitalSalem, Oregon  97309
Saint Luke's HospitalBethlehem, Pennsylvania  18015
Pocono Medical CenterEast Stroudsburg, Pennsylvania  18301
Ephrata Cancer CenterEphrata, Pennsylvania  17522
Central PA Hematology-Medical Oncology Associates PCLemoyne, Pennsylvania  17043
Riddle HospitalMedia, Pennsylvania  19063
Pottstown Memorial Medical CenterPottstown, Pennsylvania  19464
Saint Joseph Medical CenterReading, Pennsylvania  19605
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Geisinger Wyoming ValleyWilkes-Barre, Pennsylvania  18711
Mainline Health CCOPWynnewood, Pennsylvania  19096
Kent County HospitalWarwick, Rhode Island  02886
AnMed Health HospitalAnderson, South Carolina  29621
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Conklin Regional Cancer CenterAberdeen, South Dakota  57401
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Southwestern Oncology Research DepartmentBennington, Vermont  05201
Peninsula Cancer Institute-Newport NewsNewport News, Virginia  23601
Southwest VA Regional Cancer CenterNorton, Virginia  24273
Auburn Regional Medical CenterAuburn, Washington  98002
Saint Francis HospitalFederal Way, Washington  98003
Providence - Saint Peter HospitalOlympia, Washington  98506-5166
Good Samaritan Community HospitalPuyallup, Washington  98372
Northwest CCOPTacoma, Washington  98405
Multicare Health SystemTacoma, Washington  98415
Saint Clare HospitalTacoma, Washington  98499
Saint Joseph Medical CenterTacoma, Washington  98405
West Virginia UniversityMorgantown, West Virginia  26506
Langlade Hospital and Cancer CenterAntigo, Wisconsin  54409
Sacred Heart HospitalEau Claire, Wisconsin  54701
Central Wisconsin Cancer ProgramFond Du Lac, Wisconsin  54935
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Dean Hematology and Oncology ClinicMadison, Wisconsin  53717
Vince Lombardi Cancer Clinic-MarinetteMarinette, Wisconsin  54143
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Saint Michael's HospitalStevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Marshfield Clinic-Wausau CenterWausau, Wisconsin  54401
Aspirus Regional Cancer CenterWausau, Wisconsin  54401
Women and Infants HospitalProvidence, Rhode Island  02905
University of Maryland Greenebaum Cancer CenterBaltimore, Maryland  21201
Lynn Regional Cancer Center - WestBoca Raton, Florida  33428
Olathe Cancer CenterOlathe, Kansas  66061
Saint Vincent Health CenterErie, Pennsylvania  16544
Jupiter Medical CenterJupiter, Florida  33458
University of IllinoisChicago, Illinois  60612
Stony Brook University Medical CenterStony Brook, New York  11794
Horizon Oncology CenterLafayette, Indiana  47905
York HospitalYork, Maine  03909
Lahey Clinic Medical CenterBurlington, Massachusetts  01805
Saint Michael's Medical CenterNewark, New Jersey  07102
Elkhart ClinicElkhart, Indiana  46515
Washington HospitalFremont, California  94538
Marin General HospitalGreenbrae, California  94904
Memorial Healthcare System - Joe DiMaggio Children's HospitalHollywood, Florida  33021
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
Northeast Georgia Cancer Care LLCAthens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical ResearchRome, Georgia  30165
Kootenai Cancer CenterPost Falls, Idaho  83854
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-CottageGalesburg, Illinois  61401
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
DuPage Medical Group-OgdenNaperville, Illinois  60563
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Cancer Center of Kansas-LiberalLiberal, Kansas  67901
The Memorial Hospital at EastonEaston, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer CenterEaston, Maryland  21601
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer CenterBolivar, Missouri  65613
University of Missouri - Ellis FischelColumbia, Missouri  65203
Veterans AdministrationColumbia, Missouri  65201
Hackensack University Medical CCOPHackensack, New Jersey  07601
UMDNJ - New Jersey Medical SchoolNewark, New Jersey  07103
AtlantiCare Regional Medical Center -Main CampusPomona, New Jersey  08240
Carolinas Medical Center - NortheastConcord, North Carolina  28025
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
East Carolina UniversityGreenville, North Carolina  27858
Rex Cancer CenterRaleigh, North Carolina  27607
Annie Penn Memorial HospitalReidsville, North Carolina  27320
Oncology Hematology Associates of Northern PennsylvaniaDubois, Pennsylvania  15801
The Regional Cancer CenterErie, Pennsylvania  16505
Armstrong Center for Medicine and HealthKittanning, Pennsylvania  16201
Saint Mary Medical and Regional Cancer CenterLanghorne, Pennsylvania  19047
Roper HospitalCharleston, South Carolina  29401
Erlanger Medical CenterChattanooga, Tennessee  37403
Vanderbilt-Ingram Cancer Center Cool SpringsFranklin, Tennessee  37067
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
Nashville Oncology Associates PCNashville, Tennessee  37203
Saint Paul HospitalDallas, Texas  75235
West Virginia University CharlestonCharleston, West Virginia  25304
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-MequonMequon, Wisconsin  53092
Medical Consultants LimitedMilwaukee, Wisconsin  53215
Wheaton Franciscan Cancer Care - All SaintsRacine, Wisconsin  53405
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Riverview HospitalWisconsin Rapids, Wisconsin  54494
Advocate Lutheran General HospitalPark Ridge, Illinois  60068
Hope, A Women's Cancer CenterAsheville, North Carolina  28816
Magee-Womens Hospital - University of Pittsburgh Medical CenterPittsburgh, Pennsylvania  15213
Aurora Women's Pavilion of Aurora West Allis Medical CenterWest Allis, Wisconsin  53227
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida  33136
Grady Health SystemAtlanta, Georgia  30303
University of Minnesota Medical Center-FairviewMinneapolis, Minnesota  55455
FirstHealth of the Carolinas-Moore Regional HosiptalPinehurst, North Carolina  28374
Richmond University Medical CenterStaten Island, New York  10310-1699
Waverly Hematology OncologyCary, North Carolina  27518
Cancer Centers of Southwest Oklahoma ResearchLawton, Oklahoma  
Vanderbilt Breast Center at One Hundred OaksNashville, Tennessee  37204
Kaiser Permanente-Deer Valley Medical CenterAntioch, California  94531
Palchak David MDPismo Beach, California  93449
Salinas Valley MemorialSalinas, California  93901
Kaiser Permanente-Rock CreekLafayette, Colorado  80026
Connecticut Oncology and Hematology LLPTorrington, Connecticut  06790
Hematology Oncology Associates-BerwynBerwyn, Illinois  60402
Hinsdale Hematology Oncology Associates IncorporatedHinsdale, Illinois  60521
Spector, David MD (UIA Investigator)Moline, Illinois  61265
Doctors Carrol, Sheth, RaghavanLouisville, Kentucky  40215
Owensboro Mercy Medical CenterOwensboro, Kentucky  42303
Mount Clemens Regional Medical CenterMount Clemens, Michigan  48043
Comprehensive Cancer Care PCSaint Louis, Missouri  63141
Wentworth-Douglass HospitalDover, New Hampshire  03820
Coney Island HospitalBrooklyn, New York  11235
Arnot Ogden Medical CenterElmira, New York  14905
The Christ HospitalCincinnati, Ohio  45219
Cancer Care Associates-MercyOklahoma City, Oklahoma  73120
Asante Health SystemMedford, Oregon  97504
Rogue Valley Medical CenterMedford, Oregon  97504
Susquehanna Cancer CenterWilliamsport, Pennsylvania  17701
University of Tennessee - MemphisMemphis, Tennessee  38163
Legacy Salmon Creek HospitalVancouver, Washington  98686
Saint Mary's Medical CenterHuntington, West Virginia  25702
Columbia Saint Mary's Water Tower Medical CommonsMilwaukee, Wisconsin  53211
Heartland Oncology and Hematology LLPCouncil Bluffs, Iowa  51503
New York Oncology Hematology PC -Albany Medical CenterAlbany, New York  12208
New York Oncology Hematology PC - AlbanyAlbany, New York  12206
New York Oncology Hematology PC - AmsterdamAmsterdam, New York  12010
New York Oncology Hematology PC-HudsonHudson, New York  12534
New York Oncology Hematology PC - LathamLatham, New York  12110
New York Oncology Hematology PC - RexfordRexford, New York  12148
New York Oncology Hematology PC - TroyTroy, New York  12180
San Francisco General HospitalSan Francisco, California  94110
Stanford University Hospitals and ClinicsStanford, California  94305
Kaiser Permanente-FranklinDenver, Colorado  80205
Eisenhower Army Medical CenterFort Gordon, Georgia  30509
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
Providence Saint Mary Regional Cancer CenterWalla Walla, Washington  99362
Mid-Illinois Hematology Oncology AssociatesNormal, Illinois  
IU Health ArnettLafayette, Indiana  
Georgia Health Sciences UniversityAugusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick CampusBerkeley, California  94704
Boca Raton Regional HospitalBoca Raton, Florida  33486
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical CenterCedar Rapids, Iowa  52403
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PCEast Syracuse, New York  13057
Sanford Clinic North-FargoFargo, North Dakota  58102
Sanford Medical Center-FargoFargo, North Dakota  58122
Cancer Care Associates of Fresno Medical Group IncFresno, California  93720
Emory University Hospital MidtownAtlanta, Georgia  30308
Roy and Patricia Disney Family Cancer CenterBurbank, California  91505
Indiana University Health Goshen Center For Cancer CareGoshen, Indiana  46526
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Sanford Clinic North-BemidgiBemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Geisinger Medical Center-Cancer Center HazeltonHazleton, Pennsylvania  18201
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Essentia Health Cancer Center-South University ClinicFargo, North Dakota  58103
Aurora Cancer Care-BurlingtonBurlington, Wisconsin  53105
Aurora Cancer Care-FranklinFranklin, Wisconsin  53132
Aurora Cancer Care-GlendaleGlendale, Wisconsin  53212
Aurora Cancer Care-Kenosha SouthKenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee SouthMilwaukee, Wisconsin  53215
Aurora Cancer Care-RacineRacine, Wisconsin  53406-5661
Aurora Cancer Care-WaukeshaWaukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee WestWauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Illinois Cancer Specialists-NilesNiles, Illinois  60714
Bronson Battle CreekBattle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer CenterRed Bank, New Jersey  07701
Springfield Regional Medical CenterSpringfield, Ohio  45505
The James Graham Brown Cancer Center at University of LouisvilleLouisville, Kentucky  40202
Marin Cancer Care IncGreenbrae, California  94904
Lake Region Healthcare Corporation-Cancer CareFergus Falls, Minnesota  56537
Saint Louis Cancer and Breast Institute-South CitySaint Louis, Missouri  63109
PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic HospitalHarrisburg, Pennsylvania  17110
Guthrie Clinic-Robert Packer HospitalSayre, Pennsylvania  18840
PeaceHealth Southwest Medical CenterVancouver, Washington  98664
Aurora Cancer Care-Southern LakesElkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan HealthcareLa Crosse, Wisconsin  54601
Maine Center for Cancer Medicine and Blood Disorders-ScarboroughScarborough, Maine  04074
San Juan Regional Medical CenterSan Juan, New Mexico  87401
Saint Vincent's Hospital and Medical Center of New YorkNew York, New York  10011
Hudson Valley Hematology Oncology AssociatesPoughkeepsie, New York  12601
The Dyson Center for Cancer CarePoughkeepsie, New York  12601
Holy Redeemer Hospital and Medical CenterMeadowbrook, Pennsylvania  19046
Blue Ridge Medical Specialists PCBristol, Tennessee  37620
Peninsula Cancer Center-GloucesterGloucester, Virginia  23061
Peninsula Cancer Institute-WilliamsburgWilliamsburg, Virginia  23185
Columbia Saint Mary's Hospital -MilwaukeeMilwaukee, Wisconsin  53211
Cancer Care Associates-NormanNorman, Oklahoma  73071
Mercy Physicians of Oklahoma-LakesideOklahoma City, Oklahoma  73120
Medical Oncology Hematology Associates of Northern Virginia LimitedFairfax, Virginia  22031