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A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab or Placebo in Patients With Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer

Phase 3
18 Years
Open (Enrolling)
Male Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer

Thank you

Trial Information

A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab or Placebo in Patients With Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer


I. Compare the disease-free survival (DFS) of patients with lymph node-positive or
high-risk, lymph node-negative breast cancer treated with adjuvant therapy comprising
doxorubicin hydrochloride, cyclophosphamide, and paclitaxel with vs. without bevacizumab.


I. Compare the overall survival of patients treated with these regimens. II. Determine the
toxicity of these regimens. III. Compare the efficacy of short-term (20-24 weeks) vs
long-term (50-54 weeks) bevacizumab, in terms of DFS, in these patients.

IV. Evaluate the association between outcomes (disease-free survival, overall survival and
toxicities) and genotype (derived from candidate single nucleotide polymorphisms and genome
wide evaluations).

V. Compare quality of life patients treated with these regimens, in terms of physical
symptoms, physical functioning, psychological state and social functioning over an 18 month
period. (QOL closed as of 05/28/10) VI. Determine the impact of theoretical biomarker
information on patients' willingness to accept the toxicities of bevacizumab for the
estimated potential benefit.

VII. Create a biospecimen repository including plasma, serum and CellSearch cassettes
containing circulating tumor cells (CTC) for evaluating determinants of late relapse,
including candidate biomarkers reflecting occult tumor burden (e.g., CTCs and plasma tumor
DNA) and host factors (e.g., estrogen, insulin-IGF axis, inflammation, etc).

VIII. Create a biorepository of metastatic tumor samples in patients who have had a late

XV. Determine body mass index (BMI) and comorbidity burden in patients with operable breast
cancer five or more years after diagnosis.

X. Determine whether there is a relationship between late relapse and BMI at diagnosis and
at 5 years after diagnosis, and whether BMI-associated inflammatory and/or metabolic
biomarkers are associated with early and late recurrence.

OUTLINE: This is a randomized, partially double-blind, placebo-controlled, partially
open-label, multicenter study. Patients are stratified according to planned dose schedule of
doxorubicin hydrochloride and cyclophosphamide (every 3 weeks vs every 2 weeks). Patients
are further stratified according to estrogen receptor status (positive vs negative), lymph
node involvement (node-negative vs 1-3 positive node[s] vs ≥ 4 positive nodes), and
received/planned treatment (lumpectomy and whole breast radiation therapy vs lumpectomy and
accelerated partial-breast radiation therapy [before or after chemotherapy] vs mastectomy
without radiation therapy vs mastectomy [with local or regional]). Patients are randomized
to 1 of 3 treatment arms (20% of patients are randomized to Arm I, 40% to Arm II, and 40% to
Arm III).

ARM I: Patients receive doxorubicin hydrochloride IV, cyclophosphamide IV over 20-30
minutes, and placebo IV over 30-90 minutes on day 1. Treatment repeats every 2 or 3 weeks
for 4 courses. Beginning 3 weeks later, patients then receive paclitaxel IV over 1 hour on
days 1, 8, and 15 and placebo IV over 30-90 minutes on day 1. Treatment with paclitaxel and
placebo repeats every 3 weeks for 4 courses.

ARM II: Patients receive doxorubicin hydrochloride and cyclophosphamide as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 or 3 weeks for 4
courses. Beginning 3 weeks later, patients then receive paclitaxel as in arm I and
bevacizumab IV over 30-90 minutes on day 1. Treatment with paclitaxel and bevacizumab
repeats every 3 weeks for 4 courses.

ARM III: Patients receive doxorubicin hydrochloride and cyclophosphamide as in arm I and
bevacizumab as in arm II. Treatment repeats every 2 or 3 weeks for 4 courses. Beginning 3
weeks later, patients then receive paclitaxel as in arm I and bevacizumab as in arm II.
Treatment with paclitaxel and bevacizumab repeats every 3 weeks for 4 courses. Beginning 2
months later, patients then receive open-label bevacizumab IV over 30-90 minutes on day 1.
Treatment with bevacizumab alone repeats every 3 weeks for 10 courses.

In all arms, treatment continues in the absence of disease progression or unacceptable
toxicity. Patients complete quality of life (QOL) questionnaires followed by telephone QOL
interviews at baseline and periodically. (QOL closed as of 05/28/10)

After completion of study treatment, patients are followed periodically for up to 15 years.

Inclusion Criteria:

- Histologically confirmed adenocarcinoma of the breast at significant risk of distant
recurrence based on at least one of the following criteria:

- Involvement of at least one sentinel or axillary lymph node on routine
histologic examination; patients with negative sentinel nodes and negative
axillary nodes or involvement only demonstrated by immunohistochemistry are not
eligible unless they meet one of the other eligibility criteria below

- Estrogen receptor (ER) negative tumor >= 1 cm

- ER+ tumor >= 5 cm regardless of recurrence score

- ER+ tumor >= 1 cm but < 5 cm with a recurrence score >= 11; (patients enrolled
in the TAILORx trial are eligible)

- Patients must have completed definitive breast surgery including total mastectomy and
axillary dissection (modified radical mastectomy), total mastectomy and sentinel node
biopsy, breast conservation surgery and axillary dissection or breast conservation
surgery and sentinel node biopsy

- Planned post-lumpectomy radiation therapy required, including any of the following:

- Whole breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy after chemotherapy

- Accelerated partial breast radiation therapy prior to chemotherapy

- Margins of breast conservation surgery or mastectomy must be histologically free of
invasive breast cancer and ductal carcinoma in situ (DCIS); patients with resection
margins positive for lobular carcinoma in situ (LCIS) are eligible

- Time from last surgery for breast cancer (breast conservation surgery, mastectomy,
sentinel node biopsy, axillary dissection or re-excision of breast conservation
surgery margins) to planned treatment start date must be > 28 days and =< 84 days

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- Absolute neutrophil count >= 1,000/mm^3

- Platelet count >= 100,000/mm^3

- Bilirubin =< 1.5 mg/dL

- Aspartate transferase (AST) =< 2 times upper limit of normal(ULN)

- Creatinine =< 1.5 mg/dL

- Urine protein:creatinine ratio < 1.0 or 24-hour protein

- Partial thromboplastin time (PTT) =< 1.5 times ULN

- Left ventricle ejection fraction (LVEF) normal by echocardiogram (ECHO) or multigated
acquisition scan (MUGA)

- Patients who have undergone breast conservation surgery must receive radiation; prior
to randomization, the investigator must specify the planned radiation technique:

- Whole breast radiation (WBRT) after chemotherapy

- Accelerated partial breast radiation (APBI) after chemotherapy

- Accelerated partial breast radiation (APBI) prior to chemotherapy

- Post-mastectomy radiation therapy (RT) is required for all patients with a primary
tumor of >= 5 cm or involvement of 4 or more lymph nodes; post-mastectomy RT may be
administered at the investigator's discretion for all other mastectomy patients

- Patients with human epidermal growth factor receptor (HER)2 + (3+ by
immunohistochemistry [IHC] or fluorescent in situ hybridisation [FISH] ratio >= 2)
breast cancer are not eligible

- Patients with synchronous bilateral breast cancer (diagnosed =< 1 month) if the
higher TNM stage tumor meets the eligibility criteria for this trial

- Patients must not have clinical evidence of inflammatory disease or fixed axillary
nodes at diagnosis

- Patients must not have received prior cytotoxic chemotherapy or hormonal therapy for
this breast cancer; prior treatment with an anthracycline, anthracenedione or taxane
for any condition is not allowed

- Patients must not have had any major surgical procedure within 28 days of planned
treatment start date

- Patients may not have had placement of a vascular access device within 24 hours of
planned Day 1 of treatment

- Patients must not have clinically significant cardiovascular or cerebrovascular
disease, including:

Any history of

- Cerebrovascular disease including transient ischemic attack (TIA), stroke or
subarachnoid hemorrhage

- Ischemic bowel within the last 12 months

- Myocardial infarction

- Unstable angina

- New York Heart Association (NYHA) class II or greater congestive heart failure

- Grade II or greater peripheral vascular disease

- Uncontrolled hypertension defined as systolic blood pressure (SBP) > 160 or diastolic
blood pressure (DBP) > 90

- Uncontrolled or clinically significant arrhythmia

- Patients who require full-dose anticoagulation may enroll provided they meet the
following criteria:

- The patient must have an in-range International Normalized Ratio (INR) (usually
between 2 and 3) on a stable dose of warfarin or be on stable dose of low molecular
weight (LMW) heparin

- The patient must not have active bleeding or pathological conditions that carry high
risk of bleeding (e.g. varices)

- Patients must not have a bleeding diathesis, hereditary or acquired bleeding
disorder or coagulopathy

- Patients must not have a non-healing wound or fracture; patients with an
abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
within 6 months prior to randomization are not eligible

- Patients must not have hypersensitivity to paclitaxel or drugs using the vehicle
Cremophor, Chinese hamster ovary cell products or other recombinant human

- Women must not be pregnant or breast-feeding due to the potential harmful
effects of bevacizumab on the developing fetus; all females of childbearing
potential must have a blood or urine test within 7 days prior to randomization
to rule out pregnancy

- Women of childbearing potential and sexually active males must use an accepted
and effective method of contraception

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Disease-free survival (DFS)

Outcome Time Frame:

From the date of randomization to the date of first treatment failure, assessed up to 15 years

Safety Issue:


Principal Investigator

Kathy Miller

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

November 2007

Completion Date:

Related Keywords:

  • Male Breast Cancer
  • Stage IA Breast Cancer
  • Stage IB Breast Cancer
  • Stage II Breast Cancer
  • Stage IIIA Breast Cancer
  • Stage IIIB Breast Cancer
  • Breast Neoplasms
  • Breast Neoplasms, Male



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Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin  54904
Penn State Milton S Hershey Medical Center Hershey, Pennsylvania  17033
Hematology Oncology Associates Albuquerque, New Mexico  87106
The Community Hospital Munster, Indiana  46321
North Broward Medical Center Dearfield Beach, Florida  33064-3596
Wake Forest University Health Sciences Winston-Salem, North Carolina  27157
OSF Saint Francis Medical Center Peoria, Illinois  61637
Northside Hospital Atlanta, Georgia  30342
Saint Helena Hospital Saint Helena, California  94574
Saint Edward Mercy Medical Center Ft. Smith, Arkansas  72903
Mills - Peninsula Hospitals Burlingame, California  94010
Valley Medical Oncology Consultants-Castro Valley Castro Valley, California  94546
Eden Hospital Medical Center Castro Valley, California  94546
Valley Medical Oncology Consultants-Fremont Fremont, California  94538
Kaiser Permanente, Fremont Fremont, California  94538
Kaiser Permanente, Hayward Hayward, California  94545
Fremont - Rideout Cancer Center Marysville, California  95901
Community Hospital of Monterey Peninsula Monterey, California  93940
Palo Alto Medical Foundation-Camino Division Mountain View, California  94040
Bay Area Breast Surgeons Inc Oakland, California  94609
Bay Area Tumor Institution CCOP Oakland, California  94609
Tom K Lee Inc Oakland, California  94609
Kaiser Permanente-Oakland Oakland, California  94611
Palo Alto Medical Foundation Heath Care Palo Alto, California  94301
Valley Medical Oncology Consultants Pleasanton, California  94588
Valley Care Health System - Pleasanton Pleasanton, California  94588
Kaiser Permanente-Redwood City Redwood City, California  94063
Kaiser Permanente-Richmond Richmond, California  94801
Kaiser Permanente-Roseville Roseville, California  95661
Kaiser Permanente-South Sacramento Sacramento, California  95823
Kaiser Permanente - Sacramento Sacramento, California  95825
Kaiser Permanente-San Francisco San Francisco, California  94115
University of California San Francisco Medical Center-Mount Zion San Francisco, California  94115
Kaiser Permanente-Santa Teresa-San Jose San Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo, California  94806
Kaiser Permanente-San Rafael San Rafael, California  94903
Kaiser Permanente-Santa Rosa Santa Rosa, California  95403
Kaiser Permanente-South San Francisco South San Francisco, California  94080
Kaiser Permanente-Stockton Stockton, California  95210
Kaiser Permanente-Vallejo Vallejo, California  94589
Kaiser Permanente-Walnut Creek Walnut Creek, California  94596
The Medical Center of Aurora Aurora, Colorado  80012
Penrose-Saint Francis Healthcare Colorado Springs, Colorado  80907
Memorial Hospital Colorado Springs Colorado Springs, Colorado  80909
Saint Anthony Central Hospital Denver, Colorado  80204
Exempla Saint Joseph Hospital Denver, Colorado  80218
Colorado Cancer Research Program CCOP Denver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Mary Corwin Medical Center Pueblo, Colorado  81004
Danbury Hospital Danbury, Connecticut  06810
Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
Middlesex Hospital Middletown, Connecticut  06457
The Hospital of Central Connecticut New Britain, Connecticut  06050
Stamford Hospital Stamford, Connecticut  06904
Bayhealth Medical Center at Kent General Dover, Delaware  19901
Lombardi Comprehensive Cancer Center at Georgetown University Washington, District of Columbia  20057
The Watson Clinic Lakeland, Florida  33805
Cancer Centers of Central Florida PA Leesburg, Florida  34788
Atlanta Regional CCOP Atlanta, Georgia  30342
Well Star Cobb Hospital Austell, Georgia  30106
John B Amos Cancer Center Columbus, Georgia  31904
Wellstar Kennestone Hospital Marietta, Georgia  30060
Saint Joseph's-Candler Health System Savannah, Georgia  31405
Oncare Hawaii Inc-POB II Honolulu, Hawaii  96813
Oncare Hawaii Inc-Kuakini Honolulu, Hawaii  96817
University of Hawaii Honolulu, Hawaii  96813
Pacific Cancer Institute of Maui Wailuku, Hawaii  96793
Saint Luke's Mountain States Tumor Institute Boise, Idaho  83712
Saint Anthony's Health Alton, Illinois  62002
Rush - Copley Medical Center Aurora, Illinois  60504
Resurrection Healthcare Chicago, Illinois  60631
Cancer Institute at Alexian Brothers Elk Grove Village, Illinois  60007
Saint Francis Hospital Evanston, Illinois  60202
Evanston CCOP-NorthShore University HealthSystem Evanston, Illinois  60201
Hopedale Medical Complex - Hospital Hopedale, Illinois  61747
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Midwest Center for Hematology Oncology Joliet, Illinois  60432
Provena Saint Mary's Hospital Kankakee, Illinois  60901
North Shore Hematology Oncology Libertyville, Illinois  60048
Stoffel, Thomas J MD (UIA Investigator) Moline, Illinois  61265
Garneau, Stewart C MD (UIA Investigator) Moline, Illinois  61265
Sharis, Christine M MD (UIA Investigator) Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator) Moline, Illinois  61265
Good Samaritan Regional Medical Center Mt. Vernon, Illinois  62864
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
West Suburban Cancer Center River Forest, Illinois  60305
Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois  60076
Edward H Kaplan MD and Associates Skokie, Illinois  60076
Saint Margaret's Hospital Spring Valley, Illinois  61362
Carle Clinic-Urbana Main Urbana, Illinois  61801
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana  46845
Wishard Hospital Indianapolis, Indiana  46202
Saint Vincent Hospital and Health Services Indianapolis, Indiana  46260
Premier Oncology Hematology Associates Merrillville, Indiana  46410
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
McFarland Clinic Ames, Iowa  50010
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Constantinou, Costas L MD (UIA Investigator) Bettendorf, Iowa  52722
Cedar Rapids Oncology Association Cedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLC Cedar Rapids, Iowa  52402
Mercy Hospital Cedar Rapids, Iowa  52403
Saint Luke's Hospital Cedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa  50325
Genesis Medical Center - East Campus Davenport, Iowa  52803
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Capitol Des Moines, Iowa  50307
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Mercy Medical Center - North Iowa Mason City, Iowa  50401
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Covenant Medical Center Waterloo, Iowa  50702
Cancer Center of Kansas - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Stormont-Vail Regional Health Center Topeka, Kansas  66604
Saint Francis Hospital and Medical Center - Topeka Topeka, Kansas  66606
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Ochsner Clinic Foundation-Baton Rouge Baton Rouge, Louisiana  70809
Medical Center of Louisiana New Orleans, Louisiana  70112
The Union Memorial Hospital Baltimore, Maryland  21218
Associates in Oncology Hematology PC -Kensington Kensington, Maryland  20895
Associates In Oncology Hematology PC-Rockville Rockville, Maryland  20878
Caritas Saint Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Norwood Hospital Norwood, Massachusetts  02062
Berkshire Hematology Oncology PC Pittsfield, Massachusetts  01201
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
Grand Rapids Clinical Oncology Program Grand Rapids, Michigan  49503
Saint Mary's Health Care Grand Rapids, Michigan  49503
Spectrum Health at Butterworth Campus Grand Rapids, Michigan  49503
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mid-Michigan Medical Center - Midland Midland, Michigan  48670
Mercy Health Partners-Mercy Campus Muskegon, Michigan  49443
Mercy Health Partners-Hackley Campus Muskegon, Michigan  49442
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Medini, Eitan MD (UIA Investigator) Alexandria, Minnesota  56308
Miller-Dwan Hospital Duluth, Minnesota  55805
Saint Luke's Hospital of Duluth Duluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator) Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator) Fergus Falls, Minnesota  56537
Unity Hospital Fridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health System Mankato, Minnesota  56002
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Saint Cloud Hospital Saint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Saint Joseph's Hospital - Healtheast Saint Paul, Minnesota  55102
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Keesler Medical Center Kessler AFB, Mississippi  39534
Southeast Missouri Hospital Cape Girardeau, Missouri  63701
Saint John's Regional Medical Center Joplin, Missouri  64804
Freeman Health System Joplin, Missouri  64804
Missouri Cancer Care PC - Saint Charles Saint Charles, Missouri  63301
Saint Louis-Cape Girardeau CCOP Saint Louis, Missouri  63141
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Saint John's Mercy Medical Center Saint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Billings Clinic Billings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator) Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Community Medical Hospital Missoula, Montana  59801
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource Center Lincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOP Omaha, Nebraska  68106
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
Exeter Hospital Exeter, New Hampshire  03833
New Hampshire Oncology Hematology Associates Hooksett, New Hampshire  03106
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene, New Hampshire  03431
LRGHealthcare-Lakes Region General Hospital Laconia, New Hampshire  03246
Ocean Medical Center Brick, New Jersey  08724
Cooper Hospital University Medical Center Camden, New Jersey  08103
Hunterdon Medical Center Flemington, New Jersey  08822
Saint Barnabas Medical Center Livingston, New Jersey  07039
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly, New Jersey  08060
Sparta Cancer Treatment Center Sparta, New Jersey  07871
South Jersey Healthcare Vineland, New Jersey  08360
Virtua West Jersey Hospital Voorhees Voorhees, New Jersey  08043
Presbyterian Kaseman Hospital Albuquerque, New Mexico  87110
Memorial Medical Center - Las Cruces Las Cruces, New Mexico  88011
Orange Regional Medical Center Middletown, New York  10940
New York University Langone Medical Center New York, New York  10016
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division New York, New York  10025
Columbia University Medical Center New York, New York  10032
Interlakes Foundation Inc-Rochester Rochester, New York  14623
Highland Hospital Rochester, New York  14620
State University of New York Upstate Medical University Syracuse, New York  13210
Faxton-Saint Luke's Healthcare Utica, New York  13502
Mission Hospitals Inc Asheville, North Carolina  28801
Alamance Regional Medical Center Burlington, North Carolina  27216
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina  28791
Kinston Medical Specialists PA Kinston, North Carolina  28501
Marion L Shepard Cancer Center Washington, North Carolina  27889
Saint Alexius Medical Center Bismarck, North Dakota  58501
Aultman Health Foundation Canton, Ohio  44710
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Veteran Affairs Medical Center Dayton, Ohio  45428
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Kettering Medical Center Kettering, Ohio  45429
Marietta Memorial Hospital Marietta, Ohio  45750
Upper Valley Medical Center Troy, Ohio  45373
Saint Ann's Hospital Westerville, Ohio  43081
Wright-Patterson Medical Center Wright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare System Zanesville, Ohio  43701
Natalie W Bryant Cancer Center Tulsa, Oklahoma  74136
Legacy Good Samaritan Hospital and Medical Center Portland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer Center Portland, Oregon  97227
Providence Saint Vincent Medical Center Portland, Oregon  97225
Columbia River Oncology Program Portland, Oregon  97225
Salem Hospital Salem, Oregon  97309
Saint Luke's Hospital Bethlehem, Pennsylvania  18015
Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Ephrata Cancer Center Ephrata, Pennsylvania  17522
Central PA Hematology-Medical Oncology Associates PC Lemoyne, Pennsylvania  17043
Riddle Hospital Media, Pennsylvania  19063
Pottstown Memorial Medical Center Pottstown, Pennsylvania  19464
Saint Joseph Medical Center Reading, Pennsylvania  19605
Hematology and Oncology Associates of North East Pennsylvania Scranton, Pennsylvania  18508
Scranton Hematology Oncology Scranton, Pennsylvania  18510
Mercy Hospital Scranton, Pennsylvania  18501
Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania  18711
Mainline Health CCOP Wynnewood, Pennsylvania  19096
Kent County Hospital Warwick, Rhode Island  02886
AnMed Health Hospital Anderson, South Carolina  29621
Upstate Carolina CCOP Spartanburg, South Carolina  29303
Conklin Regional Cancer Center Aberdeen, South Dakota  57401
Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota  57104
Southwestern Oncology Research Department Bennington, Vermont  05201
Peninsula Cancer Institute-Newport News Newport News, Virginia  23601
Southwest VA Regional Cancer Center Norton, Virginia  24273
Auburn Regional Medical Center Auburn, Washington  98002
Saint Francis Hospital Federal Way, Washington  98003
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
West Virginia University Morgantown, West Virginia  26506
Langlade Hospital and Cancer Center Antigo, Wisconsin  54409
Sacred Heart Hospital Eau Claire, Wisconsin  54701
Central Wisconsin Cancer Program Fond Du Lac, Wisconsin  54935
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Aurora BayCare Medical Center Green Bay, Wisconsin  54311-6519
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
Vince Lombardi Cancer Clinic-Marinette Marinette, Wisconsin  54143
Bay Area Medical Center Marinette, Wisconsin  54143
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Oconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Saint Michael's Hospital Stevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Marshfield Clinic-Wausau Center Wausau, Wisconsin  54401
Aspirus Regional Cancer Center Wausau, Wisconsin  54401
Women and Infants Hospital Providence, Rhode Island  02905
University of Maryland Greenebaum Cancer Center Baltimore, Maryland  21201
Lynn Regional Cancer Center - West Boca Raton, Florida  33428
Olathe Cancer Center Olathe, Kansas  66061
Saint Vincent Health Center Erie, Pennsylvania  16544
Jupiter Medical Center Jupiter, Florida  33458
University of Illinois Chicago, Illinois  60612
Stony Brook University Medical Center Stony Brook, New York  11794
Horizon Oncology Center Lafayette, Indiana  47905
York Hospital York, Maine  03909
Lahey Clinic Medical Center Burlington, Massachusetts  01805
Saint Michael's Medical Center Newark, New Jersey  07102
Elkhart Clinic Elkhart, Indiana  46515
Washington Hospital Fremont, California  94538
Marin General Hospital Greenbrae, California  94904
Memorial Healthcare System - Joe DiMaggio Children's Hospital Hollywood, Florida  33021
Mount Sinai Medical Center CCOP Miami Beach, Florida  33140
Northeast Georgia Cancer Care LLC Athens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical Research Rome, Georgia  30165
Kootenai Cancer Center Post Falls, Idaho  83854
Illinois CancerCare-Bloomington Bloomington%, Illinois  61701
Illinois CancerCare-Canton Canton, Illinois  61520
Illinois CancerCare-Carthage Carthage, Illinois  62321
Illinois CancerCare-Eureka Eureka, Illinois  61530
Illinois CancerCare-Cottage Galesburg, Illinois  61401
Illinois CancerCare-Havana Havana, Illinois  62644
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois  61443
Illinois CancerCare-Macomb Macomb, Illinois  61455
Illinois CancerCare-Monmouth Monmouth, Illinois  61462
DuPage Medical Group-Ogden Naperville, Illinois  60563
Illinois CancerCare-Community Cancer Center Normal, Illinois  61761
Illinois CancerCare-Pekin Pekin, Illinois  61603
Illinois CancerCare-Peru Peru, Illinois  61354
Illinois CancerCare-Princeton Princeton, Illinois  61356
Illinois CancerCare-Spring Valley Spring Valley, Illinois  61362
Michiana Hematology Oncology PC-Elkhart Elkhart, Indiana  46514
Michiana Hematology Oncology PC-Plymouth Plymouth, Indiana  46563
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
Michiana Hematology Oncology-PC Westville Westville, Indiana  46391
Cancer Center of Kansas-Liberal Liberal, Kansas  67901
The Memorial Hospital at Easton Easton, Maryland  21601
Memorial Hospital at Easton - Shore Regional Cancer Center Easton, Maryland  21601
Michiana Hematology Oncology PC-Niles Niles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer Center Bolivar, Missouri  65613
University of Missouri - Ellis Fischel Columbia, Missouri  65203
Veterans Administration Columbia, Missouri  65201
Hackensack University Medical CCOP Hackensack, New Jersey  07601
UMDNJ - New Jersey Medical School Newark, New Jersey  07103
AtlantiCare Regional Medical Center -Main Campus Pomona, New Jersey  08240
Carolinas Medical Center - Northeast Concord, North Carolina  28025
Moses Cone Health System-Regional Cancer Center Greensboro, North Carolina  27403
East Carolina University Greenville, North Carolina  27858
Rex Cancer Center Raleigh, North Carolina  27607
Annie Penn Memorial Hospital Reidsville, North Carolina  27320
Oncology Hematology Associates of Northern Pennsylvania Dubois, Pennsylvania  15801
The Regional Cancer Center Erie, Pennsylvania  16505
Armstrong Center for Medicine and Health Kittanning, Pennsylvania  16201
Saint Mary Medical and Regional Cancer Center Langhorne, Pennsylvania  19047
Roper Hospital Charleston, South Carolina  29401
Erlanger Medical Center Chattanooga, Tennessee  37403
Vanderbilt-Ingram Cancer Center Cool Springs Franklin, Tennessee  37067
University of Tennessee - Knoxville Knoxville, Tennessee  37920
Nashville Oncology Associates PC Nashville, Tennessee  37203
Saint Paul Hospital Dallas, Texas  75235
West Virginia University Charleston Charleston, West Virginia  25304
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin  54729
Holy Family Memorial Hospital Manitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-Mequon Mequon, Wisconsin  53092
Medical Consultants Limited Milwaukee, Wisconsin  53215
Wheaton Franciscan Cancer Care - All Saints Racine, Wisconsin  53405
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's Hospital Stevens Point, Wisconsin  54481
Aurora Medical Center in Summit Summit, Wisconsin  53066
Vince Lombardi Cancer Clinic Two Rivers, Wisconsin  54241
Riverview Hospital Wisconsin Rapids, Wisconsin  54494
Advocate Lutheran General Hospital Park Ridge, Illinois  60068
Hope, A Women's Cancer Center Asheville, North Carolina  28816
Magee-Womens Hospital - University of Pittsburgh Medical Center Pittsburgh, Pennsylvania  15213
Aurora Women's Pavilion of Aurora West Allis Medical Center West Allis, Wisconsin  53227
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida  33136
Grady Health System Atlanta, Georgia  30303
University of Minnesota Medical Center-Fairview Minneapolis, Minnesota  55455
FirstHealth of the Carolinas-Moore Regional Hosiptal Pinehurst, North Carolina  28374
Richmond University Medical Center Staten Island, New York  10310-1699
Waverly Hematology Oncology Cary, North Carolina  27518
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma  
Vanderbilt Breast Center at One Hundred Oaks Nashville, Tennessee  37204
Kaiser Permanente-Deer Valley Medical Center Antioch, California  94531
Palchak David MD Pismo Beach, California  93449
Salinas Valley Memorial Salinas, California  93901
Kaiser Permanente-Rock Creek Lafayette, Colorado  80026
Connecticut Oncology and Hematology LLP Torrington, Connecticut  06790
Hematology Oncology Associates-Berwyn Berwyn, Illinois  60402
Hinsdale Hematology Oncology Associates Incorporated Hinsdale, Illinois  60521
Spector, David MD (UIA Investigator) Moline, Illinois  61265
Doctors Carrol, Sheth, Raghavan Louisville, Kentucky  40215
Owensboro Mercy Medical Center Owensboro, Kentucky  42303
Mount Clemens Regional Medical Center Mount Clemens, Michigan  48043
Comprehensive Cancer Care PC Saint Louis, Missouri  63141
Wentworth-Douglass Hospital Dover, New Hampshire  03820
Coney Island Hospital Brooklyn, New York  11235
Arnot Ogden Medical Center Elmira, New York  14905
The Christ Hospital Cincinnati, Ohio  45219
Cancer Care Associates-Mercy Oklahoma City, Oklahoma  73120
Asante Health System Medford, Oregon  97504
Rogue Valley Medical Center Medford, Oregon  97504
Susquehanna Cancer Center Williamsport, Pennsylvania  17701
University of Tennessee - Memphis Memphis, Tennessee  38163
Legacy Salmon Creek Hospital Vancouver, Washington  98686
Saint Mary's Medical Center Huntington, West Virginia  25702
Columbia Saint Mary's Water Tower Medical Commons Milwaukee, Wisconsin  53211
Heartland Oncology and Hematology LLP Council Bluffs, Iowa  51503
New York Oncology Hematology PC -Albany Medical Center Albany, New York  12208
New York Oncology Hematology PC - Albany Albany, New York  12206
New York Oncology Hematology PC - Amsterdam Amsterdam, New York  12010
New York Oncology Hematology PC-Hudson Hudson, New York  12534
New York Oncology Hematology PC - Latham Latham, New York  12110
New York Oncology Hematology PC - Rexford Rexford, New York  12148
New York Oncology Hematology PC - Troy Troy, New York  12180
San Francisco General Hospital San Francisco, California  94110
Stanford University Hospitals and Clinics Stanford, California  94305
Kaiser Permanente-Franklin Denver, Colorado  80205
Eisenhower Army Medical Center Fort Gordon, Georgia  30509
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
Providence Saint Mary Regional Cancer Center Walla Walla, Washington  99362
Mid-Illinois Hematology Oncology Associates Normal, Illinois  
IU Health Arnett Lafayette, Indiana  
Georgia Health Sciences University Augusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California  94704
Boca Raton Regional Hospital Boca Raton, Florida  33486
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Michiana Hematology Oncology PC-Mishawaka Mishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa  52403
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PC East Syracuse, New York  13057
Sanford Clinic North-Fargo Fargo, North Dakota  58102
Sanford Medical Center-Fargo Fargo, North Dakota  58122
Cancer Care Associates of Fresno Medical Group Inc Fresno, California  93720
Emory University Hospital Midtown Atlanta, Georgia  30308
Roy and Patricia Disney Family Cancer Center Burbank, California  91505
Indiana University Health Goshen Center For Cancer Care Goshen, Indiana  46526
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota  57117-5134
Genesys Regional Medical Center-West Flint Campus Flint, Michigan  48532
Sanford Clinic North-Bemidgi Bemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOP Duluth, Minnesota  55805
Essentia Health Saint Mary's Medical Center Duluth, Minnesota  55805
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Geisinger Medical Center-Cancer Center Hazelton Hazleton, Pennsylvania  18201
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota  58103
Aurora Cancer Care-Burlington Burlington, Wisconsin  53105
Aurora Cancer Care-Franklin Franklin, Wisconsin  53132
Aurora Cancer Care-Glendale Glendale, Wisconsin  53212
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee South Milwaukee, Wisconsin  53215
Aurora Cancer Care-Racine Racine, Wisconsin  53406-5661
Aurora Cancer Care-Waukesha Waukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana Hospital Newark, Delaware  19718
Illinois Cancer Specialists-Niles Niles, Illinois  60714
Bronson Battle Creek Battle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer Center Red Bank, New Jersey  07701
Springfield Regional Medical Center Springfield, Ohio  45505
The James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky  40202
Marin Cancer Care Inc Greenbrae, California  94904
Lake Region Healthcare Corporation-Cancer Care Fergus Falls, Minnesota  56537
Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri  63109
PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital Harrisburg, Pennsylvania  17110
Guthrie Clinic-Robert Packer Hospital Sayre, Pennsylvania  18840
PeaceHealth Southwest Medical Center Vancouver, Washington  98664
Aurora Cancer Care-Southern Lakes Elkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin  54601
Maine Center for Cancer Medicine and Blood Disorders-Scarborough Scarborough, Maine  04074
San Juan Regional Medical Center San Juan, New Mexico  87401
Saint Vincent's Hospital and Medical Center of New York New York, New York  10011
Hudson Valley Hematology Oncology Associates Poughkeepsie, New York  12601
The Dyson Center for Cancer Care Poughkeepsie, New York  12601
Holy Redeemer Hospital and Medical Center Meadowbrook, Pennsylvania  19046
Blue Ridge Medical Specialists PC Bristol, Tennessee  37620
Peninsula Cancer Center-Gloucester Gloucester, Virginia  23061
Peninsula Cancer Institute-Williamsburg Williamsburg, Virginia  23185
Columbia Saint Mary's Hospital -Milwaukee Milwaukee, Wisconsin  53211
Cancer Care Associates-Norman Norman, Oklahoma  73071
Mercy Physicians of Oklahoma-Lakeside Oklahoma City, Oklahoma  73120
Medical Oncology Hematology Associates of Northern Virginia Limited Fairfax, Virginia  22031