Ductal Lavage to Monitor and Treat High Risk Women
- Determine the volume of atypical cells collected from ductal lavage in women at
increased risk for breast cancer.
- Determine assay techniques to analyze nipple aspirate fluid and ductal lavage fluid
samples from these participants.
- Analyze the nipple aspirate fluid from these participants for specific and global
- Determine the replicability of markers in serial assays of these participants.
- Determine the percentage of participants with atypia on ductal lavage in which ductal
lesions can be identified using ductoscopy.
OUTLINE: This is a multicenter study.
Participants undergo nipple aspirate fluid and ductal lavage fluid collection. Fluid samples
are analyzed using cytological analysis, immunohistochemistry, fluorescent in situ
hybridization, or in situ polymerase chain reaction. Protein patterns are identified using
Participants found to have atypia undergo repeat lavage at 3-6 months and 1 year.
Participants with normal fluid samples undergo repeat lavage at 1 year.
PROJECTED ACCRUAL: A total of 30 participants will accrued for this study within 2-3 months.
Observational Model: Cohort, Time Perspective: Prospective
Average number of atypical cells per ductal lavage sample
Laura J. Esserman, MD, MBA
University of California, San Francisco
United States: Federal Government
|UCSF Comprehensive Cancer Center||San Francisco, California 94115|