Inclusion Criteria:

- Histologically- or cytologically- confirmed metastatic breast adenocarcinoma.

- No previous chemotherapy treatment for metastatic disease.

- No previous anthracycline treatment except as adjuvant therapy at least one year
before.

- Age 19-75 years old

- Presence of measurable disease

- Performance status 0-2 (WHO)

- Adequate cardiac function (LVEF >50%) without a recent (within 6 months) history of
myocardial infraction and/or unstable or uncontrolled angina.

- Adequate bone marrow(absolute neutrophil count >1500/mm3, platelet count
>100.000/mm3, hemoglobin >10gr/mm3), liver (bilirubin <1.5 times upper limit of
normal and SGOT/SGPT <2 times upper limit of normal) and renal function (creatinine
<2mg/dl).

- No previous radiotherapy to more than 25% of marrow-containing bones.

- Written informed consent

Exclusion Criteria:

- Active brain metastases.

- Psychiatric illness or social situation that would preclude study compliance

- Other concurrent uncontrolled illness.

- Other invasive malignancy within the past 5 years except of nonmelanoma skin cancer.

- Positive pregnancy for premenopausal women.

- Concurrent antineoplastic treatment e.g. hormonal therapy