Inclusion Criteria:

- Stage III/IV HNSCC without distant metastasis, previously untreated. Patients with
stage II squamous cell carcinoma of the hypopharynx will also be eligible.

- Adequate renal function, with serum creatinine ≤ 1.5 mg/dL. Patients with serum
creatinine > 1.5 mg/dL may be eligible if calculated creatinine clearance ≥ 55 ml/min
by Cockcroft and Gault equation (or 24-hour urine collection).

- Age ≥ 18 years

- Karnofsky performance status ≥70%

- Adequate bone marrow function: absolute neutrophil count ≥ 1,500/μl, platelets ≥
100,000/μl, hemoglobin ≥ 9 gm/dl

- Adequate hepatic function: Total bilirubin ≤ 1.5 X UNL (patients with Gilbert's
syndrome as the cause of hyperbilirubinemia may be eligible if total bilirubin ≤ 2.5
X UNL), aspartate aminotransferase (AST) ≤ 2.5 X UNL, alanine aminotransferase (ALT)
≤ 2.5 X UNL, alkaline phosphatase ≤ 2.5 X UNL.

- Men and women of childbearing potential must be willing to consent to using effective
contraception while on treatment and for at least 3 months thereafter.

- Patients must have ability to understand and the willingness to sign a written
informed consent document.

Exclusion Criteria:

- Prior chemotherapy or radiation therapy for HNSCC

- Prior treatment with bevacizumab or other agents specifically targeting VEGF

- Other active malignancy, other than indolent malignancies which the investigator
determines are unlikely to interfere with treatment or efficacy analysis. For
example, patients with non-melanoma skin cancer, in situ carcinoma of the cervix, or
prostate cancer within the no current biochemical (PSA) or radiologic evidence of
disease may enroll.

- Patients with nasopharyngeal carcinoma

- Patients who will receive amifostine as part of the radiation treatment plan

- Patients with skin breakdown/ulceration (CTCAE version 3.0, grade 2 or higher).

- Patients with hearing loss requiring hearing aid or intervention (i.e. interfering in
a clinical significant way with activities of daily living).

- Patients with multifocal peripheral sensory alterations or paresthesias (including
tingling) interfering with function, per patient report (example: activities of daily
living).

- History of arterial thromboembolic events, including transient ischemic attack (TIA),
cerebrovascular accident (CVA), unstable angina, or myocardial infarction (MI) within
the last 3 years.

- Urine protein: creatinine (UPC) ratio ≥ 1.0 at screening. A random urine sample is
collected. Total protein (mg/dL) and spot creatinine (mg/dL) are ordered for this
sample. The UPC ratio is calculated from the results of these tests.

- International normalized ratio (INR) > 1.5 or activated partial thromboplastin time
(aPTT) > 1.5 X upper limits of normal (UNL),

- Current use of warfarin, current use of heparin or low-molecular weight heparin,
chronic daily treatment with aspirin (> 325 mg/day) or nonsteroidal antiinflammatory
medications known to inhibit platelet function. Treatment with dipyramidole
(Persantine), ticlopidine (Ticlid), clopidogrel (Plavix) and or cilostazol (Pletal)
is not allowed.

- Patients with gross hemoptysis or hematemesis (defined as bright red blood of 1
teaspoon of more) within 1 month prior to Day 1 protocol treatment will be excluded
from this trial. Patients with incidental blood mixed with phlegm are not excluded.

- Esophageal varices, non-healing ulcer, wound, or bone fracture are exclusion
criteria. However, patients with skin breakdown overlying malignant neck
lymphadenopathy may be eligible, at the discretion of the investigator.

- Anatomic lesion that increases the risk of serious hemorrhage, such as encasement or
invasion of major blood vessels by primary tumor and/or by involved lymph nodes

- Blood pressure of > 150/100 mmHg

- New York Heart Association (NYHA) Grade II or greater congestive heart failure.

- Clinically significant peripheral vascular disease

- History of bleeding diathesis or hemorrhagic disorder, or coagulopathy.

- Major surgical procedure or significant traumatic injury within 28 days prior to
treatment with bevacizumab

- Core biopsy within 15 days prior to treatment with bevacizumab.

- Minor surgical procedures such as fine needle aspirations or placement of
percutaneous gastrostomy tube (PEG) less than 7 days prior to treatment with
bevacizumab

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 6 months prior enrollment.

- Inability to comply with study and/or follow-up procedures

- Women who are pregnant or lactating