Inclusion Criteria:

Women carrying benign breast lesions will be further divided and analyzed according to the
Fitzgibbon's risk categories for invasive cancer risk (4). The Fitzgibbon's categories
are:

1. No increased risk group including adenosis (other than sclerotic), duct ectasia
fibroadenoma without complex features,

2. slightly increased risk group (1.5-20 times) which includes fibroadenoma with complex
features, moderate or florid hyperplasia without atypia, sclerosing adenosis,

3. moderately increased risk group (4.0-5.0 times) includes atypical ductal and lobular
hyperplasia and

4. markedly increased risk group (8.0-10.0 times) which includes ductal and lobular
carcinomas In Situ Following the blood collection, detailed relevant clinical
information of the patient will be registered in a case record form.

The data will include: age, country of birth, last menstrual period, lactation, number of
children, age at first full-term pregnancy, age at onset of menopause, family history,
medication, mammography findings, FNA results, tumor size, histological findings,
biopsies, disease staging, and other relevant clinical information.

Exclusion Criteria:

1. pregnancy,

2. experiencing menstruation, or

3. under hormonal or drug treatment.