Inclusion Criteria:

- Histologically or cytologically confirmed malignant solid tumor (at diagnosis)

- Relapsed or refractory tumors in which correct standard treatment approaches have
failed

- Measurable primary and/or metastatic disease: at least one bi-dimensionally
measurable lesion. For patients with neuroblastoma, measurable disease will be
defined by the modified International Neuroblastoma Staging System (Brodeur et
al.1993). For patients with osteosarcoma, measurable lesions are lung metastases and
osseous lesions with soft tissue tumor, in exclusion of completely calcified or
necrosed lesion at study entry. A patient with an unique osseous lesion without soft
tissue mass can be included in the study if the lesion is operable and thus
accessible for histological response assessment.

- No more than one salvage therapy for relapse

- Age at inclusion: 6 months to ≤ 20 years

- Lansky play score ≥ 70% or ECOG performance status ≤ 1

- Life expectancy ≥ 3 months

- Adequate organ function:

- Adequate hematological function: neutrophil count >= 1.0 x 10^9/L, platelet
count >= 100 x 10^9/L; in case of bone marrow disease: >= 75 x 10^9/L;
hemoglobin >= 8 g/dL

- Adequate renal function: creatinine > 1.5 x ULN for age; If serum creatinine is
> 1.5 ULN of age, then creatinine clearance (or radioisotope GFR) must be > 70
ml/min/1.73 m2 Adequate hepatic function: bilirubin > 1.5 x ULN; AST and ALT >
2.5 x ULN (AST, ALT ≤ 5 x ULN in case of liver metastases).

- Wash out of 3 weeks in case of prior chemotherapy, 6 weeks if treatment included
nitrosoureas, 2 weeks in case of vincristine alone; 4 weeks in case of prior
radiotherapy. Patients must have recovered from the acute toxic effects of all prior
therapy before enrollment into the study.

- Able to comply with scheduled follow-up and with management of toxicity

- All patients with reproductive potential must practice an effective method of birth
control while on study. Female patients with childbearing potential must have a
negative pregnancy test within 7 days before study treatment.

- Written informed consent from patient, parents or legal guardian

Exclusion Criteria:

- Concurrent administration of any other antitumor therapy.

- Have previously completed or withdrawn from this study or any other study
investigating gemcitabine or oxaliplatin.

- Have a serious concomitant systemic disorder (for example, active infection including
HIV or cardiac disease) that in the opinion of the investigator, would compromise the
patient's ability to complete the study

- Pre-existing sensory or motor neuropathy >Grade 2 (excluding neuropathy due to
disease and/or surgery)

- History of allergic reaction to platinum compounds

- Are pregnant or breast feeding

- Presence of symptomatic brain metastases in patients with solid non-central nervous
system (CNS) tumors