Inclusion Criteria:

1. Patients are eligible if they have newly diagnosed histologically confirmed locally
advanced or metastatic tumors of the pancreas. Patients must be felt to be
unresectable by surgical criteria or felt to be medically inoperable. Patients may
also be Stage IV with metastatic disease to the liver. Patients with bone and/or lung
metastasis may be included at the investigators discretion.

2. Patients must have measurable disease by CT scan.

3. Patients must be able to give informed consent. Patients must be older than 18 years
of age.

4. Patients should have adequate bone marrow, renal, and hepatic function including:
Bilirubin less than 1.25 x institutional normal LDH SGPT, SGOT, and alkaline
phosphatase less than3 x institutional normal Serum creatinine less than or equal to
3 mg/dl. Absolute neutrophil count of greater than 1500 Hemoglobin greater than 9 gm
per dl Platelet count greater than 100,000 WBC greater than 3000 cells per mcl

5. Women of child-bearing potential must be agreeable to adequate
contraception.(hormonal or barrier method of birth control) prior to study entry and
for the duration of study participation.)

6. Patients must have a Karnofsky performance status of greater than or equal 60 or
Zubrod of less or equal to 2.

7. Life expectancy of at least 3 months.

8. May have had a second malignancy or multiple malignancies if adequately controlled by
clinical means. patients with more than one type of cancer must be cleared by the
principal investigator.

9. Patients must be at least 1 week from any major operative procedure.

10 .Patients may have brain metastasis if these brain metastasis are well controlled by
usual clinical criteria and if the life expectancy is at least 3 months. Any patient with
brain metastasis must be cleared by the principal investigator.

Exclusion Criteria:

1. Active infection requiring intravenous (IV) antibiotics at the time of entry.

2. Cerebral metastasis which has not been adequately controlled.

3. Significant malnutrition, cachexia, inundation or inability to give informed consent
by clinical assessment.

4. Concurrent chemotherapy not prescribed in this protocol.

5. Any significant medical problems such as diabetes, cardiomyopathy or hypertension
which is not reasonably controlled

6. Prior radiation or chemotherapy