ChronoFOLFOX Plus Avastin for Patients With Metastatic Colorectal Cancer
The purpose of this study is to determine if treatment with 5-Fluorouracil, leucovorin,
oxaliplatin, and Avastin will cause colorectal tumor cells to shrink or disappear. The
study will also determine the safety of these drugs when given together and the quality of
life of the patients who are enrolled in the study.
It is thought that these drugs will be better tolerated if they are chronomodulated, i.e.,
if they are given at certain times of day rather than as a continuous infusion.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
The primary objective is to determine if the rate of adverse events among patients receiving chronoFOLFOX plus Avastin is acceptable compared to that in previous studies using the FOLFOX4 regimen.
Petra Ketterl, MD
Cancer Treatment Centers of America at Southwestern Regional Medical Center, Inc.
United States: Institutional Review Board
|Cancer Treatment Centers of America at Southwestern Regional Medical Center, Inc.||Tulsa, Oklahoma 74133|