Inclusion Criteria:

- 1.Previously untreated newly diagnosed patients with MM (stage II-III) 2.Age < 65
3.Eastern Cooperative Oncology Group Performance Status 0-1 4.EF > 50%, FVC and FEV >
50%, DLCO >50% 5.Platelet count ≥ 100 x 109/L (pretreatment platelet transfusion is
not allowed, while transfusion during the treatment is permitted), hemoglobin ≥ 8
g/dL (≥ 4.96 mol/L), Prior RBC transfusion or recombinant human erythropoietin use is
allowed), absolute neutrophil count (ANC) ≥ 1.0 x 109/L 6.Adequate liver function
(bilirubin < UNL(Upper Normal Limit) x 2 and ALT/AST < UNL x 3) 7.Adequate renal
function (serum creatinine < UNL x 1.5 or creatine clearance > 60 ml/min) 8.Signed
the informed consent, have the will and ability to follow the protocol

Exclusion Criteria:

- 1. History of allergic reaction attributable to compounds containing boron or
mannitol 2. Known hypersensitivity to thalidomide or dexamethasone 3. Peripheral
neuropathy or neuropathic pain Grade 2 or higher as defined by NCI CTCAE version 3 4.
Uncontrolled or severe cardiovascular disease, including MI within 6 months of
enrollment, New York Heart Association (NYHA) Class III or IV heart failure,
uncontrolled angina, clinically significant pericardial disease, or cardiac
amyloidosis 5. Acute severe infection requiring antibiotic therapy 6. Previous cancer
history (except in situ carcinoma of cervix or basal cell cancer of skin) 7.
Pregnancy or breastfeeding 8. Active ulcer detected by gastroscopy (gastroscopy is
not routine in all patients, only to patients with symptoms of ulcer disease and/or
history of previous ulcer therapy and/or physician's discretion) 9. Previous renal
transplantation 10. Recurrent deep vein thrombosis or pulmonary embolism 11.
Uncontrolled diabetes mellitus 12. Receipt of extensive radiation therapy within 4
weeks ((Extensive means RT to more than 2 anatomic sites).