Comparison of I-124 PET/CT, F-18 FDG PET/CT and I-123 Whole Body Scintigraphy for Recurrent Thyroid Cancer Detection
18 Years
N/A
Both
Thyroid Cancer
Trial Information
Comparison of I-124 PET/CT, F-18 FDG PET/CT and I-123 Whole Body Scintigraphy for Recurrent Thyroid Cancer Detection
The management of thyroid cancer patients with suspicion of recurrent disease based on
rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body
scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected.
The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT
may allow better identification of recurrent disease, thus allowing for more patients to be
treated with I-131 as a curative attempt.
Conducting this study we hope to find whether I-124 PET/CT allows for detection of more
lesions in patients with suspected recurrent thyroid cancer than the current standard of
care represented by I-123 WBS and F-18 FDG PET/CT.
Inclusion Criteria:
- Patient at Nuclear Medicine clinic at Stanford University MedicalCenter
- Treated thyroid cancer.
- Detectable levels of Tg.
- Referred for I-123 WBS and F-18 FDG PET/CT for detection of recurrent thyroid cancer.
- Able to have a I-124 PET/CT the day after I-123 WBS and F-18 FDG PET/CT
- Patients older than 18-year-old.
- Patients with history of treated thyroid cancer and suspected recurrent thyroid
cancer based on detectable levels of Tg.
- Patients must have I-123 WBS and F-18 FDG PET/CT performed prior to the I-124 PET/CT.
- Patients must understand and voluntarily sign an Informed Consent form after the
contents have been fully explained to them.
Exclusion Criteria:- Patients who are not eligible for I-123 WBS and F-18 FDG PET/CT.
- Patients who cannot complete I-123 WBS and F-18 FDG PET/CT.
- Pregnant women.
- Healthy volunteers.
- Patients participating in other research studies.
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Principal Investigator
Andrei Iagaru
Investigator Role:
Principal Investigator
Investigator Affiliation:
Stanford University
Authority:
United States: Institutional Review Board
Study ID:
END0003
NCT ID:
NCT00373711
Start Date:
May 2007
Completion Date:
Related Keywords:
- Thyroid Cancer
- Thyroid Neoplasms
- Thyroid Diseases
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