Validation of a Score of Predictive Factors for Complete Resection in Platinum-sensitive Recurrent Ovarian Cancer
The multicentre retrospective study AGO-DESKTOP OVAR 1 investigated in a multicentre-setting
the question of prognostic factors for a successful (i.e. complete) debulking for
recurrence. That way, a hypothesis for a score with 3 factors could be developed:
- PS ECOG = 0
- tumor-free after primary surgery (if unknown: FIGO I/II)
- Ascites < 500 ml.
The goal of this study is to evaluate in a prospective multicentre setting, to what extent
this retrospectively defined AGO-score has predictive validity. The criterion aimed at is
therefore the rate of complete tumor resections if the three score characteristics are
present in invasive epithelial platinum-sensitive ovarian-, fallopian tube- or primary
peritoneal cancer. This study will be the second in a series of three: (1) hypothesis
building for a potential predictive score for resectability, (2) prospective confirmation of
the AGO-score, and (3) application of the AGO-score as inclusion criteria for eligible
patients in whom a formal comparison of the role of secondary debulking of relapsed ovarian
cancer could be performed.
Observational Model: Cohort, Time Perspective: Prospective
Philipp Harter, Dr.
Dr. Horst Schmidt Klinik Wiesbaden
Germany: Ethics Commission