Inclusion Criteria:

1. Patient is between 18 and 60, inclusive

2. Patients who have completed L-FMAU-301 or L-FMAU-302 clinical trial.

3. Patient is HBsAg positive at week 48 in L-FMAU-301 or L-FMAU-302.

4. Patient has bilirubin levels less than 2.0 mg/dL, prothrombin time of less than 1.7
(INR), a serum albumin level of at least 3.5 g/dL at week 48 in L-FMAU-301 or
L-FMAU-302.

5. Women of childbearing potential must have a negative serum (β-HCG) pregnancy test at
screening.

6. Patient is able to give written informed consent prior to study start and to comply
with the study requirements.

Exclusion Criteria:

1. Patients with HBV DNA < 4,700 copies/mL, ALT normalization and consecutive e
seroconversion at week 40 and 48 in L-FMAU-301

2. Patients with HBV DNA < 4,700 copies/mL and ALT normalization in L-FMAU-302

3. Patient is currently receiving antiviral, immunomodulatory or corticosteroid therapy.

4. Patients previously treated with α-interferon, lamivudine, lobucavir, adefovir or any
other investigational nucleoside for HBV infection.

5. Patient has a history of ascites, variceal hemorrhage or hepatic encephalopathy.

6. Patient is coinfected with HCV, HDV or HIV.

7. Patient with clinical evidence of liver mass or hepatocellular carcinoma and
α-Fetoprotein > 50 ng/mL

8. Patient is pregnant or breast-feeding.

9. Patient is unwilling to use an “effective” method of contraception during the study
and for up to 3 months after the use of study drug ceases. For males, condoms should
be used. Females must be surgically sterile (via hysterectomy or bilateral tubal
ligation) or post-menopausal or using at least medically acceptable barrier method of
contraception (i.e. IUD, barrier methods with spermicide or abstinence)

10. Patient has a clinically relevant history of abuse of alcohol or drugs.

11. Patient has a significant gastrointestinal, renal, hepatic (decompensated),
bronchopulmonary, biliary diseases excluding asymptomic GB stone, neurological,
cardiovascular, oncologic or allergic disease. The patient with a benign tumor except
for liver mass, excluded if judged by an investigator that the continuation of study
would be interfered by the tumor.

12. Patient has creatinine clearance less than 60mL/min as estimated by the following
formula:

(140-age in years) (body weight [kg])/(72)(serum creatinine [mg/dL]) [Note: multiply
estimates by 0.85 for women]

13.Patient whom investigator consider is not suitable in this study