Use of Rosuvastatin in Integral Management of Abdominal Sepsis
The sepsis is often lethal, the mortality's ranks are identified among 25 to 70%, this
depends on definition, severity and co-morbidities. The number of deaths by sepsis could be
similar to myocardial infarct. Patients who get shock have 26-fold risk of death.
In preliminary studies have been observed, that patients with treatment with statin have
minor incidence of severe sepsis. A retrospective study suggests the association between
using statins and reduction of bacteriemia by Gram negatives and S. aureus.
There are many experimental studies which demonstrate the possible profit in sepsis. However
there are no clinical prospective studies for determinate if statins are effective in
management of sepsis. The investigators designed this study to demonstrate the utility of
rosuvastatin in one kind of sepsis, abdominal sepsis.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Plasmatic levels of Interleukine 6 and 1B, and Tumor Necrosis Factor alpha (pg/dL)
Martin Sanchez-Aguilar, MSc
Experimental Surgery , Universidad Autonoma de San Luis Potosi
Mexico: National Institute of Public Health, Health Secretariat