A Randomised Double Blind Placebo Controlled, Parallel Pilot Study to Test the Effect of Testosterone Replacement on Glycaemic Control and Arterial Wall Properties of Hypogonadal Men With Type 2 Diabetes Treated With Insulin
There is epidemiological data linking low serum testosterone levels in men with the
development of diabetes. Clinical trials have indicated a potential benefit of testosterone
treatment in improving diabetic control and insulin resistance. Type 2 diabetes is also
associated with changes in arterial stiffness and IMT which are known to be linked to the
presence of cardiovascular disease. Artificially induced hypogonadism results in increasing
arterial stiffness whilst testosterone is known to improve risk factors for vascular disease
and act as a vasodilator. The purpose of this pilot study is to test the effect of six
months of testosterone replacement, given as testosterone esters 200mg from Sustanon 250 IM
injection, on diabetes control in hypogonadal men with type 2 diabetes treated with insulin.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
The effect of 6 months of testosterone replacement on diabetes control measured by HbA1c in hypogonadal men with type 2 diabetes treated with insulin.
Hugh Jones, BSc MD FRCP
Barnsley Hospital NHS Foundation Trust
United Kingdom: National Health Service