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Case-Control Study of Renal Cell Cancer Among Caucasians and African Americans in the United States

20 Years
79 Years
Not Enrolling
Kidney Cancer

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Trial Information

Case-Control Study of Renal Cell Cancer Among Caucasians and African Americans in the United States

Incidence rates of renal cell cancer have increased rapidly in the U.S. and other countries.
In particular, rates among African Americans have risen more sharply than any other cancer
site. We propose to conduct a population-based case-control study of renal cell cancer two
areas of the U.S. with a high proportion of African American residents: Detroit, Michigan
(Wayne State University), and Chicago, Illinois (University of Illinois at Chicago).
Westat, Inc. is the coordinating center. Participants are being recruited over a period of
four years. A total of 2,100 cases (1,400 Caucasian Americans and 700 African Americans)
and 2,800 controls (1,400 each of Caucasian and African Americans) will be recruited.
In-person interviews are conducted with cases and controls to elicit information on
demographic background and history of exposures. A 40 ml blood sample and a buccal cell
sample are collected from cases and controls for genetic analyses. Tumor tissue blocks will
be collected from as many cases as possible for assays of tumor mutations. Diagnostic
slides will be collected for standardized reclassification of tumors into clear cell,
papillary, and other histologic subtypes. Medical records for all cases will be reviewed
for presenting symptoms, tumor stage, size and grade, and methods leading to diagnosis of
renal cell cancer. Telephone interviews are conducted with the nest-of-kin of eligible
cases who died before we could interview them. Permission is being sought from the
next-of-kin to assess the case's medical records and obtain tumor tissue samples.

Inclusion Criteria


Residents of the study areas who are diagnosed with histologically confirmed renal cell
carcinoma at ages 20 to 79 years over a four year study will be potentially eligible for
the study.

In addition, only eligible patients who are mentally/physically able to provide informed
consent and undergo interviews will be approached for participation.


Population-based controls will be frequency-matched to the cases by study center, race,
age and sex, at the ratio of one control per case for non-African Americans and two
controls per case for African Americans.

Controls aged 65 years and older will be identified from Health Care Financing
Administration (HCFA) files.

Controls under age 65 years will be identified from residents of the study areas by random
telephone digit dialing (RDD).

Type of Study:


Study Design:


Principal Investigator

Mark P Purdue, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

November 2001

Completion Date:

Related Keywords:

  • Kidney Cancer
  • Diet
  • Exposure
  • Hypertension
  • Kidney Cancer
  • Occupation
  • Carcinoma, Renal Cell
  • Kidney Neoplasms



University of Illinois at ChicagoChicago, Illinois  60612
Wayne State UniversityDetroit, Michigan  48202