Know Cancer

or
forgot password

Comparison of HIV-1 Epitopes That May be Recognized by HLA-B*3501 (PY) and -B*3503 (Px) Early After Seroconversion and After Development of AIDS


N/A
21 Years
N/A
Not Enrolling
Both
HIV-1, AIDS

Thank you

Trial Information

Comparison of HIV-1 Epitopes That May be Recognized by HLA-B*3501 (PY) and -B*3503 (Px) Early After Seroconversion and After Development of AIDS


The purpose of this study is to identify variations in the genome of HIV early after
infection and following the development of AIDS to determine the location of escape
mutations that might provide information about potential B*35 epitopes. These data will be
useful in explaining the difference in disease progression between individuals possessing
B*35 Px alleles and those with B*35 PY alleles. We have previously shown that individuals
with B*35 Px alleles progress at a significantly faster rate compared to those with B*35 PY
alleles. This study might provide information which is potentially useful in the
development of a successful HIV vaccine.

Inclusion Criteria


- INCLUSION AND EXCLUSION CRITERIA:

Sera and relevant clinical data from properly consented HIV positive seroconverters will
be provided to the LGD for analysis. No available subjects will be excluded to maximize
power. We will request an accrual ceiling of 100 participants.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

999905237

NCT ID:

NCT00340223

Start Date:

September 2005

Completion Date:

September 2007

Related Keywords:

  • HIV-1
  • AIDS
  • Immunity
  • Mutations
  • Viral Selection
  • Disease Progression
  • RNA
  • Acquired Immunodeficiency Syndrome

Name

Location
National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland  20892
John H. Stroger, Jr. Hospital of Cook County Chicago, Illinois  60612-9985
University of Pittsburgh Pittsburgh, Pennsylvania  15261
Northwestern University Chicago, Illinois  60611
University of California, Los Angeles Los Angeles, California  
Howard Brown Health Center Chicago, Illinois  60613
John Hopkins Bloomberg School of Public Health Baltimore, Maryland