Inclusion Criteria:

- Written informed consent given.

- Patients who are able to understand the study request.

- Men and women > or = 18 years, not hospitalized.

- Outpatients with ECOG performance status ≤ 2.

- Histologically confirmed diagnosis of colorectal cancer (CRC) patients with
metastasis.

- Presence of at least one detectable lesion in accordance with Response Evaluation
Criteria in Solid Tumors (RECIST) criteria.

- Life expectancy of greater than 3 months.

- Men and women potentially fertile using an effective contraceptive method

Exclusion Criteria:

- Patients who have been treated with bevacizumab previously.

- Received any systemic treatment previously to treat an advanced or metastatic disease

- Adjuvant or neoadjuvant treatment to non-metastatic disease is allowed, provided
that it has been finished at least 6 months before the initial study treatment.

- If the patient has been treated with adjuvant therapy previously, it is not
allowed to be included in the study in case of disease progression during
treatment or for 6 months after the end of treatment.

- If radiotherapy has not been administered in the lesion selected for the study,
previous radiotherapy is allowed, unless progression of those injuries can be
documented in the radiated field, as long as the end of the treatment has been
finished at least 4 weeks before study initiation.

- Previous surgical procedure of stage IV disease is allowed.

- Previous malignancies other than adequately treated in situ carcinoma of the uterine
cervix, basal or squamous cell carcinoma of the skin, or this study indication,
unless there has been a disease-free interval of at least 2 years.

- History or evidence upon physical examination of central nervous system

- History of psychiatric disability judged by the investigator to be clinically
significant precluding informed consent or interfering with compliance for oral drug
intake.

- Clinically significant cardiovascular disease (active).

- Patients who have undergone myocardial infarction or cerebrovascular accident 6
months prior to randomisation will be excluded.

- Lack of physical integrity of the upper gastrointestinal tract, malabsorption
syndrome or inability to take oral medications.

- Patients subjected to allogeneic transplant and request immunotherapy.

- Bone fracture not healed, wounds or severe ulcers.

- Known hemorrhagic diathesis or coagulopathy.

- Uncontrolled and severe intercurrent infections or other severe and uncontrolled
concomitant diseases.

- Moderate or severe renal impairment (creatinine clearance < 30 ml/min [calculated
according to Cockroft-Gault formula] or serum creatinine ≥ 2 mg/dl or 177 μmol/l).

- Any of the following laboratory values:

- Absolute neutrophil count (ANC) ≤ 1.5 x 10^9/l.

- Platelet count ≤ 100 x 10^9/l.

- Hemoglobin ≤ 9 g/dl.

- International Normalized Ratio (INR) ≥ 1.5.

- Total bilirubin ≥ 1.5 x upper limit of normal (ULN).

- ALT and/or AST ≥ 2.5 x ULN or ≥ 5 x ULN (in case of hepatic metastasis).

- Alkaline phosphatase > 2.5 x ULN or 5 x ULN (in case of hepatic metastasis), or
> 10 x ULN (in case of bone metastasis).

- History of unexpected serious adverse events to fluoropyrimidine treatments or known
dihydropyrimidine dehydrogenase (DPD) deficiency.

- Patients subjected to major surgical procedure or open biopsy; or patients have had
significant traumatic injuries 28 days before the initial study treatment; or
patients with a major surgical procedure planned during the study period.

- Fine needle aspiration biopsy 7 days before study initiation.

- Use of full dose of oral or parenteral anticoagulants (at least 10 days before the
initial study treatment) or thrombolytic agents. Low dose of warfarin is allowed,
with an INR ≤ 1.5.

- Subjects requiring chronic use of high dose aspirin (> 325 mg/day) or non-steroidal
anti-inflammatory treatment (those known to inhibit platelet function at doses used
to treat chronic inflammatory diseases).

- Pregnant or lactating women.

- Patients with known allergy to Chinese hamster ovary cell proteins or other
recombinant human or humanized antibodies; or to any excipients of bevacizumab
formulation; or to any other study drugs.

- Received any investigational drug or agent/procedure, i.e. participation in another
treatment trial within 30 days of randomisation.

- Evidence of another disease, metabolic malfunction, discovery in a physical
examination or in a clinical laboratory test to result in reasonable suspicion of a
condition or disease that contraindicates investigational medicine use or exposes the
patient to high risk treatment complications.