Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women
A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting
steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via
random periareolar fine needle aspiration in postmenopausal women at increased risk for
breast cancer and taking hormone replacement therapy.
- postmenopausal women on or off hormone replacement therapy
- at high risk of developing breast cancer determined by family or personal history
- postmenopausal women not on hormone replacement therapy for at minimum six months
prior to corresponding aspiration
- willing to participate in companion protocol (KUMC HSC#4601) for random periareolar
fine needle aspiration (RPFNA) for correlational studies
- women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane
within the six months prior to RPFNA.
Type of Study:
Observational Model: Cohort, Time Perspective: Prospective
Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates.
develoment of algorithm for prediction of risk of developing breast cancer.
Outcome Time Frame:
Carol J Fabian, MD
University of Kansas
United States: Institutional Review Board
- Breast Cancer
- single nucleotide polymorphism
- breast atypia
- breast epithelial hyperplasia
- high risk for breast cancer
- Breast Neoplasms
|University of Kansas Medical Center||Kansas City, Kansas 66160-7353|