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Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women


N/A
18 Years
N/A
Open (Enrolling)
Female
Breast Cancer

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Trial Information

Correlation of SNP Patterns With Fine Needle Aspiration Cytomorphology in High Risk Postmenopausal Women


A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting
steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via
random periareolar fine needle aspiration in postmenopausal women at increased risk for
breast cancer and taking hormone replacement therapy.


Inclusion Criteria:



- postmenopausal women on or off hormone replacement therapy

- at high risk of developing breast cancer determined by family or personal history

- postmenopausal women not on hormone replacement therapy for at minimum six months
prior to corresponding aspiration

- willing to participate in companion protocol (KUMC HSC#4601) for random periareolar
fine needle aspiration (RPFNA) for correlational studies

Exclusion Criteria:

- women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane
within the six months prior to RPFNA.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates.

Outcome Description:

develoment of algorithm for prediction of risk of developing breast cancer.

Outcome Time Frame:

ongoing

Safety Issue:

No

Principal Investigator

Carol J Fabian, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Kansas

Authority:

United States: Institutional Review Board

Study ID:

9814

NCT ID:

NCT00329017

Start Date:

May 2005

Completion Date:

May 2014

Related Keywords:

  • Breast Cancer
  • SNPs
  • single nucleotide polymorphism
  • breast atypia
  • breast epithelial hyperplasia
  • high risk for breast cancer
  • Breast Neoplasms

Name

Location

University of Kansas Medical CenterKansas City, Kansas  66160-7353