Trial Information

Thoracoscopic Resection of Subcentimetre Lung Nodules After Localization Using Percutaneous Inserted Platinum Microcoil Under CT Guidance: a Pilot Study

Lung cancer is the most common cause of cancer death for both men and women in the
industrialized world. Small cell lung cancer accounts for about 25% of lung cancers and is
usually widespread when it first presents. The remaining 75% of lung cancers are
collectively termed non-small cell lung cancers. When presentation is by symptoms or
incidental discovery, about 50 to 60% of non-small cell lung cancers are parenchymal nodules
or masses and 40 to 50% are bronchial or hilar. More than 50% of patients with non-small
cell cancer will have distant metastases at the time of diagnosis and only 25% will be
potentially resectable for cure.1 Overall survival at five years for lung cancer is
approximately 15% and has not significantly improved over the last several decades.
Prognosis for lung cancer is affected by many factors but one of the most important is the
stage of the disease at presentation. Individuals with peripheral lesions less than 3 cm in
diameter (T1) at presentation are ideal candidates for surgical resection and have the best
outcomes, with 5-year survival rates as high as 60 to 80%.2 Patients with small
subcentimeter pulmonary nodes may have even better survival with resection. Computed
tomography can now detect cancers less than 4 mm in diameter, and it has been shown that
resection of subcentimetre lung cancers results in a survival rate of up to 85%.3 However,
Suzuki et al found 54% of 92 patients undergoing video assisted thoracoscopic excision of
subcentimetre nodules, required conversion to a thoracotomy. Forty percent of those nodules
were found to be malignant.4 The most common reason for this conversion was failure to
localize the nodule using thoracoscopic visualization or palpation. Furthermore, univariate
and multivariate analysis of eleven variables revealed that if the distance from the pleural
surface was greater than 5 mm, the probability of failure to detect the nodule was 63%.