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Effect of Helicobacter Pylori on the Availability of Vitamin E and C

Phase 4
18 Years
45 Years
Open (Enrolling)
Heliobacter Pylori Infection

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Trial Information

Effect of Helicobacter Pylori on the Availability of Vitamin E and C

It has been postulated that dietary antioxidants may reduce cancer risk by modulating red-ox
status, by preventing biological oxidation, and by inhibiting the formation of carcinogen.
However, supplementation studies and prospective studies have yielded contradictory results.
In the case of gastric cancer, H.pylori infection, which is known to be associated with a
higher risk of the disease, results in an increased production of ROS & RNS. As a result
serum levels of these free radicals increase, exerting a higher demand for dietary
antioxidants to neutralize them.

The fact that the relation between serum levels of antioxidants and gastric cancer is more
consistent than that of dietary intake levels and the disease suggests the possibility of
the presence of an intrinsic factor that is altering the true relation between dietary
antioxidants and the cancer. This intrinsic factor, this study argues, is the infection with

H.pylori infection, by increasing the production of reactive oxygen species, increases the
utilization of dietary antioxidants that serve in quenching the free radicals, thus
decreasing their serum levels and confounding their protective effect against gastric
cancer. The purpose of this pilot study is to investigate the possibility that H.pylori
infection alters the bioavailability of the dietary antioxidants: vitamin C, and vitamin E.
This project will be done in preparation for an etiologic study of dietary antioxidants and
gastric cancer.

Inclusion Criteria:

- Adult , age 18-45

Exclusion Criteria:

1. Smoking

2. Body mass index below 18 or above 25.

3. Previous treatment for H.pylori infection

4. Partial or total gastrectomy

5. History of gastritis

6. Currently taking antioxidants supplementation

7. Training in an athletic team.

8. Drinking more than 3 servings of alcohol/day

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

plasma vitamin C levels

Principal Investigator

Farah Naja, MSc.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Canada: Cancer Care Ontario


Canada: University of Toronto

Study ID:




Start Date:

March 2006

Completion Date:

September 2007

Related Keywords:

  • Heliobacter Pylori Infection
  • heliobacter pylori infection
  • reactive oxygen species
  • antioxidants