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NYU Lung Cancer Biomarker Center


N/A
50 Years
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

NYU Lung Cancer Biomarker Center


OBJECTIVES:

- Identify and validate biomarkers for the early detection of lung cancer in individuals
at low- or high-risk for smoking-related cancers.

- Identify preneoplastic cellular changes and lesions in these patients.

OUTLINE: Participants are stratified according to lung cancer risk status (with or without
increased risk).

Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary
function testing, multidetector chest CT scan, sputum induction, and phlebotomy.

Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the
same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy
based upon CT scan results with transbronchial or endobronchial biopsies. Some participants
may undergo lung resection. Tissue samples are collected from surgery or biopsy.

PROJECTED ACCRUAL: A total of participants will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Screening Cohort

- At high- or low-risk for lung cancer

- Smoking history ≥ 20 pack years*

- With or without workplace exposure to asbestos

- NOTE: * Participants with < 20 pack years of smoking are eligible if 50 years of age
or older

- Rule-Out Lung cancer group

- Referred for evaluation of suspicious nodules with 1 of the following diagnoses:

- Lung cancer

- Nonmalignant nodules (control group)

PATIENT CHARACTERISTICS:

- Not pregnant

- No prior malignancy except nonmelanoma skin cancer

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Lung cancer diagnosis as measured by CT scan findings and pathology findings annually

Outcome Time Frame:

07/01/2015

Safety Issue:

No

Principal Investigator

William N. Rom, MD, MPH

Investigator Role:

Principal Investigator

Investigator Affiliation:

New York University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

CDR0000456198

NCT ID:

NCT00301119

Start Date:

May 2000

Completion Date:

Related Keywords:

  • Lung Cancer
  • small cell lung cancer
  • non-small cell lung cancer
  • smoker lung cancer screening
  • low dose spiral CT screening
  • Lung Neoplasms

Name

Location

NYU Cancer Institute at New York University Medical CenterNew York, New York  10016