Modelling Internal Hepatic Movement With an External Abdominal Marker Block for Use With a Real Time Position Monitoring System for Respiratory Gating
18 Years
N/A
Both
Patients With Liver Metastases From Colorectal Cancer
Trial Information
Modelling Internal Hepatic Movement With an External Abdominal Marker Block for Use With a Real Time Position Monitoring System for Respiratory Gating
The study will use a real time position management (RPM) system for respiratory gating. The
RPM system senses the respiration motion of the patient by tracking a pair of reflective
markers on a lightweight "marker block" constructed of a synthetic material. This block is
placed on the patient's abdomen.
During Radiotherapy, the beam is only switched on at pre-determined phases of respiration.
The appropriate phase of respiration is determined by the RPM system. This implies a
reliable correlation of external block motion to internal hepatic movement. This correlation
is not a simple one, and requires "modeling".
Inclusion Criteria:
- Histologically confirmed adenocarcinoma compatible with primary disease in the colon
or rectum
- Aged 18 years or older
- Unequivocal contrast-enhanced CT and/or MRI evidence of malignant single or multiple
metastases in the liver, metastases at other sites will not be an exclusion criterion
- WHO performance status 0-2 and life expectancy of at least 12 weeks
- Informed written consent
Exclusion Criteria:
- Pregnancy or breast feeding
- Evidence of ascites
- Patients unable for whatever reason to lie flat
- Patients unable to give fully informed consent
- Age< 18 years
Type of Study:
Observational
Study Design:
Time Perspective: Prospective
Principal Investigator
Dr Diana Tait
Investigator Role:
Principal Investigator
Investigator Affiliation:
Royal Marsden HNHS Foundation Trust
Authority:
United Kingdom: Medicines and Healthcare Products Regulatory Agency
Study ID:
CCR 2736
NCT ID:
NCT00299299
Start Date:
June 2006
Completion Date:
Related Keywords:
- Patients With Liver Metastases From Colorectal Cancer
- Colorectal Neoplasms
- Neoplasm Metastasis
- Liver Neoplasms
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