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Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women


N/A
18 Years
N/A
Not Enrolling
Female
Breast Cancer

Thank you

Trial Information

Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women


To examine nipple aspirate fluid analysis in lactating women for local concentration of
estrogen, prolactin, glucocorticoids, insulin, parity, prior lactation and age. NAF
secretors have been reported to have modest increase in breast cancer risk compared to
non-secretors . Estrogen levels have been found to be markedly higher in NAF samples than
in the serum collected from the same women. Estradiol and estrone concentrations in
premenopausal women are 10x and 20x greater in NAF samples than in serum and 50x and 35x
greater in post-menopausal women not on HRT. It has been suggested that the disparity
between serum and NAF levels may be due to local estrogen production via aromatase and
sulfatase.


Inclusion Criteria:



- women with high a high risk of breast cancer

- Older than 18

Exclusion Criteria:

- anticoagulants

- marked breast tenderness

- pregnant or within twelve months of breast feeding/childbirth

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Carol J Fabian, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Kansas

Authority:

United States: Institutional Review Board

Study ID:

8427

NCT ID:

NCT00291083

Start Date:

October 2005

Completion Date:

June 2008

Related Keywords:

  • Breast Cancer
  • NAF
  • nipple aspirate fluid
  • breast atypia
  • high risk for breast cancer
  • breast epithelial hyperplasia
  • Ki-67
  • hormones plus chemoprevention
  • chemoprevention
  • Breast Neoplasms

Name

Location

University of Kansas Medical CenterKansas City, Kansas  66160-7353