Inclusion Criteria

Inclusion criteria

To be eligible, patients must :

- Be male or female, age 18-65

- Be diagnosed with schizophrenia, schizoaffective disorder or bipolar disorder with
psychotic features according to DSM-IV criteria

- Be currently receiving antipsychotic drugs (clozapine, haloperidol, olanzapine,
quetiapine, or risperidone) (APDs) alone, mood stabilizer(s) (MS) alone, or a
combination of the two

- Have a history of compliance with the above medication

- Have presumptive IRS as indicated by a TG/HDL ratio > 3.5 on current antipsychotic
medication

- Be Medicaid eligible or maintain insurance covering requested lab procedures

- Be able to provide written informed consent Exclusion criteria

A patient will be considered ineligible if he/she:

- Has a diagnosis other than schizophrenia, schizoaffective disorder or bipolar
disorder with psychotic features according to DSM-IV criteria.

- Has a history of noncompliance with prescribed psychiatric medications

- Has a TG/HDL ratio < 3.5 on current medication

- Is uninsured or is unable to self-pay potential costs of required lab procedures not
covered by insurance.

- Is unable to provide written informed consent.

- (Females only) Is pregnant, lactating or plans to become pregnant during study
participation

Exclusion Criteria:

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