Identification of Novel Genetic Risk Factors That Contribute to the Risk for Breast Cancer
Breast cancer takes its greatest toll on younger women, as it is the leading category of
cancer deaths for women 20-39 years of age. Sadly, survival rates are lowest among women
diagnosed at a young age. This impact is most significant among African-American women who
have the highest incidence and mortality rate among women less than 45 years of age. The
goal of our program is to identify the genetic factors which distinguish breast cancer in
younger women compared to older women.
Women who were diagnosed with invasive breast cancer 40 years of age or younger are invited
to participate. The age at diagnosis is used to determine eligibility, not a woman's current
age. Women who have undergone genetic testing of the BRCA1, BRCA2, p53, pTEN, e-cadherin, or
LKB1 genes are eligible to participate. Young women with breast cancer are asked to: sign a
consent form, submit a sample of blood, release their cancer related records, and answer
some family history questions.
We will use a family based case control approach in our analysis. As such, if a woman's
parents are living, they will be invited to participate as a "comparison" group. The parents
are asked to: sign a consent form, submit a sample of blood, and release any cancer records.
A woman does not have to live in St. Louis to participate. All study related materials can
be mailed directly to the young woman or her parents. There is no expense to the family. All
materials are kept strictly confidential and participation is completely voluntary.
Observational Model: Family-Based, Time Perspective: Prospective
Jennifer L Ivanovich, MS
Washington University School of Medicine
United States: Institutional Review Board
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