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Identification of Novel Genetic Risk Factors That Contribute to the Risk for Breast Cancer


N/A
18 Years
80 Years
Open (Enrolling)
Female
Breast Cancer Invasive Nos

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Trial Information

Identification of Novel Genetic Risk Factors That Contribute to the Risk for Breast Cancer


Breast cancer takes its greatest toll on younger women, as it is the leading category of
cancer deaths for women 20-39 years of age. Sadly, survival rates are lowest among women
diagnosed at a young age. This impact is most significant among African-American women who
have the highest incidence and mortality rate among women less than 45 years of age. The
goal of our program is to identify the genetic factors which distinguish breast cancer in
younger women compared to older women.

Women who were diagnosed with invasive breast cancer 40 years of age or younger are invited
to participate. The age at diagnosis is used to determine eligibility, not a woman's current
age. Women who have undergone genetic testing of the BRCA1, BRCA2, p53, pTEN, e-cadherin, or
LKB1 genes are eligible to participate. Young women with breast cancer are asked to: sign a
consent form, submit a sample of blood, release their cancer related records, and answer
some family history questions.

We will use a family based case control approach in our analysis. As such, if a woman's
parents are living, they will be invited to participate as a "comparison" group. The parents
are asked to: sign a consent form, submit a sample of blood, and release any cancer records.

A woman does not have to live in St. Louis to participate. All study related materials can
be mailed directly to the young woman or her parents. There is no expense to the family. All
materials are kept strictly confidential and participation is completely voluntary.


Inclusion Criteria:



- Women diagnosed with invasive breast cancer 40 years of age or younger. If their
parents are living, the parents are also invited to participate, regardless of their
history of cancer.

Exclusion Criteria:

- Women diagnosed with in-situ breast cancer.

Type of Study:

Observational

Study Design:

Observational Model: Family-Based, Time Perspective: Prospective

Principal Investigator

Jennifer L Ivanovich, MS

Investigator Role:

Study Director

Investigator Affiliation:

Washington University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

04-1009

NCT ID:

NCT00276120

Start Date:

March 2005

Completion Date:

January 2015

Related Keywords:

  • Breast Cancer Invasive Nos
  • Breast
  • Cancer
  • Young
  • Women
  • Breast Neoplasms

Name

Location

Washington University School of MedicineSaint Louis, Missouri  63110