Inclusion Criteria:

1. women between age of 45 and 55 and suffered from hot flushes and/or sweats

2. had not participated in any trial within the previous 3 months before beginning this
study

3. were willing to participate in the trial and give written informed consent

Exclusion Criteria:

1. had received any form of hormonal therapy within 3 months prior to the study

2. had been diagnosed with any form of cancer and under treatment

3. were afflicted with abnormal uterine bleeding and unknown etiology

4. had hypertension or diabetes mellitus and were under treatment for these conditions

5. had any abnormal finding for kidney, liver, or thyroid functions

6. were currently taking antidepressants, alpha or beta-blocking agent, e.g., clomidine,
ergot, ergot derivatives, or anti-estrogen medications such as tamoxifen and/or
herbal hormones (isoflavon

7. were suffering from arrhythmia or any other form of heart disease.