Inclusion Criteria:

1. Age 18 to 75 years

2. Histologically proven adenocarcinoma

3. At least one "measurable" lesion (by RECIST)

4. No prior chemotherapy for gastric cancer

5. WHO performance status ≦ 2

6. Adequate baseline organ functions

7. Fasting serum triglyceride level > 70 mg/dL

8. Written informed consent

9. At least one month from gastrectomy

10. Availability of tumor sample for immunohistochemical or pharmacogenomic testing of
EGFR

Exclusion Criteria:

1. Concomitant anti-cancer biological agents, chemotherapy, or radiotherapy

2. CNS metastasis

3. Pregnancy, breast-feeding women and women of child-bearing potential

4. Life expectancy less 3 months

5. Serious concomitant illness

6. Concurrent or prior second malignancy

7. Known hypersensitivity reaction to any of the components of study treatments