Trial Information

Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis

Patients with ulcerative colitis (UC) are at increased risk for colon cancer. Current
guidelines recommend periodic surveillance colonoscopy in individuals who fulfill certain
high-risk criteria. Endoscopists must perform a high number of biopsies (over 33 per
patient) in order to increase the yield of such procedures. Chromoendoscopy (CE) has the
ability to identify subtle lesions that are otherwise missed by standard endoscopy. Whether
CE can replace standard colonoscopy in the surveillance of patients with UC is unknown.

Comparison: both standard biopsies and targeted biopsies will be obtained during colonoscopy
from patients with UC who are candidates for surveillance colonoscopy. The yield of the two
methods will be compared based on the number of biopsies required to identify one dysplastic
(precancerous) lesion.