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Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis


N/A
18 Years
N/A
Not Enrolling
Both
Ulcerative Colitis, Crohn's Disease

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Trial Information

Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis


Patients with ulcerative colitis (UC) are at increased risk for colon cancer. Current
guidelines recommend periodic surveillance colonoscopy in individuals who fulfill certain
high-risk criteria. Endoscopists must perform a high number of biopsies (over 33 per
patient) in order to increase the yield of such procedures. Chromoendoscopy (CE) has the
ability to identify subtle lesions that are otherwise missed by standard endoscopy. Whether
CE can replace standard colonoscopy in the surveillance of patients with UC is unknown.

Comparison: both standard biopsies and targeted biopsies will be obtained during colonoscopy
from patients with UC who are candidates for surveillance colonoscopy. The yield of the two
methods will be compared based on the number of biopsies required to identify one dysplastic
(precancerous) lesion.


Inclusion Criteria:



- Ulcerative colitis, pancolitis > 8 years; left-sided > 15 years or

- history of PSC or

- history of previous dysplasia on colon biopsies or

- family history of colon cancer in first degree relative

Exclusion Criteria:

- any condition that precludes colonoscopy

- expected survival less than 1 year

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Prevalence of dysplastic lesions by white light vs. chromoendoscopy

Outcome Time Frame:

12 months

Safety Issue:

No

Principal Investigator

Michael V Chiorean, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Indiana University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

0509-71

NCT ID:

NCT00274209

Start Date:

December 2005

Completion Date:

November 2011

Related Keywords:

  • Ulcerative Colitis
  • Crohn's Disease
  • Ulcerative colitis
  • Crohn's disease
  • Chromoendoscopy
  • Dysplasia
  • Neoplasia
  • Colitis
  • Colitis, Ulcerative
  • Crohn Disease
  • Ulcer

Name

Location

Indiana University Medical CenterIndianapolis, Indiana  46202