Inclusion Criteria:

1. Men and women, at least 18 years old, with histologically confirmed, advanced stage
IIIB or IV NSCLC for whom no curative options exist and for whom docetaxel and
carboplatin is a reasonable treatment option;

2. At least 1 target lesion that is unidimensionally measurable as defined by the
Response Evaluation Criteria in Solid Tumors (RECIST) and has not been previously
irradiated;

3. Eastern Cooperative Oncology Group Performance Status of 0 or 1, (determined within 2
weeks prior to receiving study medication;

4. Ability to understand and adhere to the protocol requirements, and give informed
consent

5. Use of effective means of contraception (men and women) in subjects of child-bearing
potential. Child-bearing potential is defined as follows: A woman of childbearing
potential is a sexually mature woman who has not undergone a hysterectomy or who has
not been naturally postmenopausal for at least 12 consecutive months (i.e., who has
had menses at any time in the preceding 12 consecutive months).

Exclusion Criteria:

1. Patients who have had docetaxel in nonradiosensitizing therapy

2. Patients who have received prior full dose systemic chemotherapy for NSCLC (ie
neoadjuvant, adjuvant, or metastatic) within the last 6 months.

3. ECOG status of 2 or greater

4. Screening clinical laboratory values:*ANC of <1,500/µL *Platelet count of <75,000/µL
* INR >/= 1.5 *T bilirubin elevation above normal (MDACC upper normal limit is 1.0
mg/dL) *Serum creatinine of >2.0 mg/dL *Hemoglobin of <9 mg/dL (may be transfused or
receive epoetin alfa [e.g., Epogen®] to maintain or exceed this level) *The pt is
ineligible if: 1.alk phos>5xULN; 2.AST or ALT >5xULN; 3.alk phos >1xULN but 2.5xULN AND AST or ALT >1.5xULN but 2.5xULN but or ALT > 1xULN but2.5xULN but >1.5xULN but
5. Inability to comply with study and/or follow-up procedures

6. History of other disease, active infection, metabolic dysfunction , physical
examination finding, or clinical laboratory finding which is uncontrolled requiring
medical intervention giving reasonable suspicion of a disease or condition that
contraindicates the use of an investigational drug or that might affect the
interpretation of the results of the study or render the subject at high risk from
treatment complications.

7. Current, recent (within 4 weeks of the first infusion of this study), or planned
participation in an experimental drug study other than a bevacizumab cancer study

8. Prior exposure to anti-VEGF therapy

9. Blood pressure of > 140/90 mmHg as documented in two consecutive blood pressure
readings within 4 hours

10. Any prior history of hypertensive crisis or hypertensive encephalopathy

11. New York Heart Association (NYHA) Grade II or greater congestive heart failure

12. History of myocardial infarction or unstable angina within 6 months

13. History of stroke or transient ischemic attack within 6 months

14. Significant vascular disease (e.g., aortic aneurysm, aortic dissection)

15. Evidence of bleeding diathesis or coagulopathy

16. Presence of central nervous system or brain metastases at any time

17. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to Day 0, anticipation of need for major surgical procedure during the course
of the study

18. Minor surgical procedures, fine needle aspirations or core biopsies within 7 days
prior to Day 0

19. Pregnant (positive pregnancy test) or lactating

20. Proteinuria at screening as demonstrated by either: Urine protein:creatinine (UPC)
ratio > 1.0 at screening OR Urine dipstick for proteinuria > 2+ (patients discovered
to have > 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour
urine collection and must demonstrate < 1g of protein in 24 hours to be eligible).

21. History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 6 months prior to Day 0

22. Serious, non-healing wound, ulcer, or bone fracture

23. Lung carcinoma of squamous cell histology or any histology in close proximity to a
major vessel, cavitation.

24. History of hemoptysis (bright red blood of 1/2 teaspoon or more)

25. Full dose anticoagulation, chronic use of Aspirin (>325 mg/day) or NSAIDs

26. Inability to comply with study and/or follow-up procedures