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Ultra-Sensitive, Infra-Red Thermographic Analysis of Kaposi's Sarcoma Skin Lesions


N/A
18 Years
N/A
Open (Enrolling)
Both
Sarcoma

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Trial Information

Ultra-Sensitive, Infra-Red Thermographic Analysis of Kaposi's Sarcoma Skin Lesions


OBJECTIVES:

Primary

- Compare ultra-sensitive infrared thermographic images with visible light digital
photographic images and clinical dermatologic examination as methods of measuring
cutaneous lesions in patients with Kaposi's sarcoma (KS).

Secondary

- Compare differences in modulation of temperature detected in KS skin lesions with
non-involved skin of the same patient and with normal skin of healthy volunteers by
sequential imaging using the infrared thermographic camera.

OUTLINE: This is a controlled, pilot study.

Patients undergo clinical assessment followed by simultaneous digital photographic camera
imaging and high-resolution infrared thermographic camera imaging of designated normal skin
areas and selected marker lesions. Before imaging, a metal bar chilled to 0º C, 10º C, and
25º C is applied to the lesions and designated normal skin areas for up to 90 seconds.

Healthy volunteers (controls) undergo the same procedure as for the patient except only
designated normal skin areas are used.

PROJECTED ACCRUAL: A total of 20 patients and 10 healthy volunteers (controls) will be
accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Histologically confirmed cutaneous Kaposi's sarcoma (KS)

- At least one skin lesion accessible for imaging

- HIV positivity with proven cutaneous KS and concurrent visceral or mucous
membrane involvement allowed

- Healthy volunteer (regardless of HIV status) (control)

PATIENT CHARACTERISTICS:

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Other

- Pregnancy allowed

PRIOR CONCURRENT THERAPY:

- Prior topical, intralesional, or systemic treatment allowed

Type of Study:

Interventional

Study Design:

Primary Purpose: Diagnostic

Principal Investigator

Ciro Martins, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Sidney Kimmel Comprehensive Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000452799

NCT ID:

NCT00265902

Start Date:

November 2004

Completion Date:

Related Keywords:

  • Sarcoma
  • Kaposi sarcoma
  • Sarcoma, Kaposi
  • Sarcoma

Name

Location

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, Maryland  21231-2410