Inclusion Criteria:

1. Histologic proof of previous colorectal adenocarcinoma (not carcinoid, squamous cell
cancer, gastrointestinal stromal tumor, or lymphoma)

2. Contrast-enhanced spiral CT scan of the thorax, and a tri-phasic CT scan of the
abdomen and pelvis performed within 30 days (plus up to 14 days) before randomization
demonstrating resectable metastasis(es) that are isolated to the liver

3. Full colonoscopy performed within the preceding 18 months showing no evidence of
malignancy (other than a synchronous colorectal primary expected to be removed at
time of liver resection)

4. Age over 18 years

Exclusion Criteria:

1. Extrahepatic disease including enlarged portal lymph nodes on CT

2. Prior liver resection

3. Previous radiofrequency ablation of malignant liver lesion

4. Systemic chemotherapy within three weeks prior to randomization

5. Radiotherapy within two months prior to randomization

6. Significant concurrent medical problems (e.g., uncontrolled diabetes, active cardiac
disease, significant chronic obstructive pulmonary disease) making the patient unfit
for surgery

7. Pregnant or lactating female

8. Unable to lie supine for imaging with PET

9. Previously treated cancer other than non-melanocytic skin cancer or carcinoma in situ
of the cervix, unless disease-free for 5 years or greater

10. Patients who, at the time of the initial evaluation, have already undergone a whole
body PET within 6 months prior to randomization