Inclusion Criteria:

- Head and Neck cancer locally advanced (oral cavity, oropharynx, hypopharynx or
larynx) but without evident metastasis.

- Inoperable tumor after revision by a multidisciplinary oncology team.

- Proved epidermoid carcinoma.

- ECOG = 0-1

- Good hematologic function (i.e, hemoglobin > 10 g/dl, ...)

- Good hepatologic function

- Good renal function

Exclusion Criteria:

- Pregnant or breast-feeding women. Potential child-bearing women should use an
effective conceptive method and should have a negative pregnancy test at least the
week before entering the study.

- Nasopharynx, nasal cavity and paranasal sinusitis will be excluded

- Previous chemotherapeutic or radiotherapeutic treatment for this disease.

- Previous or current neoplasms in other locations, except in situ cervicouterine
cancer properly treated or basal cell or squamous cell carcinoma

- Symptomatic peripheral neuropathy

- Other clinical severe diseases

- Concomitant treatment with corticoids within 6 months prior to inclusion.

- Concomitant treatment with any other neoplastic therapy

- Previous treatment for current disease.

- Loss of weight greater than 10% within the last 3 months.

The above information is not intended to contain all considerations relevant to a
patient's potential participation in a clinical trial.