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Early Evaluation of the Response of Large B Cell Non Hodgkin’s Lymphoma to Chemotherapy by Positron Emission Tomography Coupled With Computed Tomography (PET/CT)


N/A
18 Years
70 Years
Open (Enrolling)
Both
Lymphoma, Large-Cell

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Trial Information

Early Evaluation of the Response of Large B Cell Non Hodgkin’s Lymphoma to Chemotherapy by Positron Emission Tomography Coupled With Computed Tomography (PET/CT)


Participation in this study involves 4 PET/CT exams, which occur before the treatments
start, after the first cycle of chemotherapy, after 4 cycles of chemotherapy and then 12
weeks after the end of the treatments. The only additional test performed in this study
compared to the regular follow-up of patients that are not in this study is the PET/CT exam
after the first cycle. Your participation in this study will not affect treatment since the
results of the first PET/CT test will not be communicated. All other tests results will be
available in the medical record.


Inclusion Criteria:



- Newly diagnosed large B cells non Hodgkin’s lymphoma, CD20 positive

- Chemotherapy treatments planned (R-CHOP) but not started

Exclusion Criteria:

- Pregnancy (determined by urinary β-HCG and blood test)

- Patients younger than 18 years

- Unable to tolerate the procedure (30 minutes laying down on the back)

- No chemotherapy treatment planned secondary to the patient's health performance

- Previous lymphoma that has been treated with chemotherapy with the exception of stade
I lymphoma treated only with radiotherapy.

- All lymphoma other than large cell Non Hodgkin’s lymphoma

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Disease free survival at 2 years

Principal Investigator

Eric Turcotte, MD, FRCPC

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Hospitalier Universitaire de Sherbrooke

Authority:

Canada: Health Canada

Study ID:

CRC 05-020

NCT ID:

NCT00256490

Start Date:

November 2005

Completion Date:

November 2009

Related Keywords:

  • Lymphoma, Large-Cell
  • Diffuse large B cells lymphoma
  • PET/CT
  • FDG
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse

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