Know Cancer

or
forgot password

A Phase I, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Weekly Intravenous INNO-105 in Adult Patients With Advanced Solid Malignancies


Phase 1
18 Years
N/A
Not Enrolling
Both
Tumors

Thank you

Trial Information

A Phase I, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Weekly Intravenous INNO-105 in Adult Patients With Advanced Solid Malignancies


Inclusion Criteria:



1. Have a histologically or cytologically confirmed diagnosis of a solid malignancy
(patients may have either measurable or nonmeasurable disease).

2. Be ≥18 years old.

3. Not eligible for effective therapy likely to provide clinical benefit.

4. Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤2.

5. Acceptable pretreatment clinical laboratory results.

6. Life expectancy of greater than 12 weeks.

Exclusion Criteria:

1. Have received previous treatment with INNO-105.

2. Have an active, uncontrolled systemic infection considered opportunistic, life
threatening, or clinically significant at the time of treatment.

3. Are pregnant or lactating.

4. Have a psychiatric disorder(s) that would interfere with consent, study
participation, or follow-up.

5. Have received any chemotherapy, immunotherapy, vaccines, monoclonal antibodies, major
surgery, or irradiation, whether conventional or investigational, within 2 weeks of
treatment in this study.

6. Have not recovered from acute toxicity of all previous therapy prior to enrollment.

7. Have symptomatic or untreated central nervous system (CNS) metastases.

8. Have a susceptibility to hypotension, bradycardia, and/or hypopnea, such as patients
with known coronary heart disease, arrhythmias, cerebral vascular disease, and
chronic obstructive airways disease (CO2-retaining).

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Principal Investigator

Casey Cunningham, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mary Crowley Medical Research Center

Authority:

United States: Food and Drug Administration

Study ID:

INNO-105-901

NCT ID:

NCT00255333

Start Date:

November 2005

Completion Date:

March 2007

Related Keywords:

  • Tumors

Name

Location

Mary Crowley Medical Research CenterDallas, Texas  75246
University of Maryland Greenebaum Cancer CenterBaltimore, Maryland  21201