Inclusion Criteria

INCLUSION CRITERIA:

- Signed written informed consent form in accordance with institutional guidelines

- Histologically confirmed primary or metastatic CNS malignancy (Patients with
metastatic disease must have histological confirmation of the primary cancer AND
confirmation by surgical specimen, cerebrospinal fluid cytology, elevated tumor
markers, or clinical evidence of CNS involvement)

- Single or multiple cerebellar or cerebral cortex lesions allowed

- Life expectancy at least 60 days

- Radiographically evaluable disease by MRI or CT scan

- Age 18 years or older

- At least 28 days since prior radiotherapy (systemic, cranial, and/or spinal)

- At least 28 days since prior chemotherapy (42 days for nitrosoureas)

- Adequate cardiac and pulmonary function to tolerate general anesthesia

- Performance status of ECOG 0-2

- Other tumor masses in the spinal cord allowed provided there is no radiographic or
clinical evidence of spinal cord block

- Available for follow-up for at least one year following completion of treatment

- Fertile patients must use effective contraception for 2 months prior to, during, and
for 3 months after study participation

- Pre-treatment lab tests within 14 days prior to initiation of treatment:

- WBC > 2,500/mm^3

- Absolute granulocyte count > 1,200/mm^3

- Platelet count > 100,000/mm^3

- Hematocrit > 30% (transfusion allowed)

- Bilirubin ≤ 2 times upper limit of normal (ULN)

- SGOT ≤ 3 times ULN

- Creatinine ≤ 2 times ULN

- Subjects with history of smoking or emphysema require DLCO ≥ 80% of predicted value
for age

- Histological sections submitted for pathology review

EXCLUSION CRITERIA:

- Radiographic evidence of excessive intra-cranial mass effect and/or spinal block

- Known hypersensitivity or intolerance to melphalan

- NCI CTC Grade 3 or greater baseline neurologic symptoms

- Immunologically compromised (Concurrent corticosteroids for tumor edema allowed)

- Unable to tolerate general anesthesia

- Pregnant, positive HCG test, or lactating

- HIV positive

- Receiving concurrent radiotherapy or immunotherapy

- Serious illness that would preclude study participation