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CSF-1 and Other Cytokines in Human Endometrial Carcinogenesis

Open (Enrolling)
Uterine Neoplasms, Endometrial Neoplasms

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Trial Information

CSF-1 and Other Cytokines in Human Endometrial Carcinogenesis

These experiments, taken together, should critically determine if there is a role for the
CSF-1/ c-fms autocrine, endocrine, or paracrine loop in the progression of endometrial
adenocarcinoma. If so, alterations in this loop may provide novel medical therapies for
this disease. Additionally, these experiments will determine which are the predominant
cytokines expressed in these tumors, and will help the investigators to determine the role,
if any, these cytokines play in cancer cell growth and proliferation in relationship with
each other and within and outside of the estrogen-mediated pathways.

Inclusion Criteria:

- All patients undergoing hysterectomy, or who have endometrial cancer, and are under
routine surveillance.

- Patients may have received prior hormonal, cytotoxic chemotherapy, irradiation or
surgical therapy.

- Healthy post-menopausal and peri-menopausal women.

- A consent form must be signed by the patient prior to study entry.

Exclusion Criteria:

- Patients who do not have primary uterine corpus tumors.

- Patients with less than one gram of tumor tissue available to procurement.

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Principal Investigator

Harriet Smith, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of New Mexico


United States: Institutional Review Board

Study ID:




Start Date:

January 1998

Completion Date:

January 2022

Related Keywords:

  • Uterine Neoplasms
  • Endometrial Neoplasms
  • Corpus Uteri
  • Endometrium
  • Cancer
  • Neoplasms
  • Endometrial Neoplasms
  • Uterine Neoplasms
  • Adenoma



University of New Mexico Albuquerque, New Mexico  87131