Hepatic Arterial Infusion of Oxaliplatin Clinical Trial
After entry qualification and registration patients will undergo hepatic artery
catheterization via interventional radiology. The catheter will remain in place for two
hours while oxaliplatin is infused and then be removed. This treatment will be followed by a
48 hour infusion of 5FU and leucovorin, generally following the principle of FOLFOX 6. These
cycles of therapy will be repeated biweekly for six episodes. Hepatic tumor size will be
evaluated by CT scan to determine if resectability has been established as the result of
tumor size reduction. If so, the patient will be offered resection of the residual lesions
in an effort to achieve long term survival.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
number of patients who become eligible for total resection of metastatic liver tumor
Robert K Ausman, M. D.
Dept. Surgery, Medical College of Wisconsin
United States: Institutional Review Board
|Medical College of Wisconsin/ Froedtert Hospital||Milwaukee, Wisconsin 53226|