Inclusion Criteria:

- Newly diagnosed primary invasive ductal or invasive lobular breast adenocarcinoma

- Tumor classified as clinically large T2 (2-5 cm), T3, T4 or any T with N1, N2

- Prior malignancies: limited to curatively treated basal or squamous carcinoma of the
skin or history of previous malignancies, treated and now > 5 years disease free

- >= 18 years of age

- Normal left ventricular function by echocardiogram or radioventriculogram

- Karnofsky Performance >= 70

Exclusion Criteria:

- No evidence of distant metastasis present by CT, Bone scan, or physical exam

- If the bone scan or CT scans demonstrate indeterminate lesions, the nature of these
lesions may be further clarified by additional testing such as PET or MRI

- No current treatment with Zometa or other bisphosphonates

- No serious functional disorders of the liver or kidneys:

- Serum Creatinine <=2

- ALT/AST/ALK Phos <= 1.5 x upper limit of institutional normal.

- Bili <= 1.5 x upper limit of institutional normal.

- Currently not pregnant