Defining the Extent and Grade of Prostate Cancer Using Dynamic Contrast Enhanced Diffusion Weighted and BOLD MRI
18 Years
N/A
Male
Prostate Cancer
Trial Information
Defining the Extent and Grade of Prostate Cancer Using Dynamic Contrast Enhanced Diffusion Weighted and BOLD MRI
The purpose of this study is to determine the ability of functional MRI techniques [High
Resolution Dynamic Contrast Enhanced MRI (HR-DCE-MRI), diffusion weighted MRI (DWI) and BOLD
MRI] to detect, measure and locate intra-prostatic cancer. 70 patients undergoing MRI for
staging of prostate cancer prior to radical prostatectomy will be studied. Results of MRI
will be correlated with pathologic specimens to determine MRI accuracy.
Inclusion Criteria
Patients will be recruited from the University Health Network (UHN). Eligible patients
will be undergoing radical prostatectomy for prostate cancer at UHN. Patients with a
contraindication to MRI or MRI contrast agents, claustrophobia, renal failure, allergy to
MRI contrast agents, or prior hormonal therapy or radiation therapy for prostate cancer, a
biopsy within 3 weeks of the surgical date or active prostatitis will be excluded.
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Principal Investigator
Masoom Haider, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University Health Network, Toronto
Authority:
Canada: Health Canada
Study ID:
05-0387-CE
NCT ID:
NCT00242112
Start Date:
June 2005
Completion Date:
Related Keywords:
- Prostate Cancer
- Prostatic Neoplasms
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