PET and MRI in the Follow-up of Neoadjuvant Chemotherapy of Breast Cancer
PET/CT with FDG-(18F) and FLT-(18F) and MRI are performed at the initial staging, 3 times
during sequential adjuvant chemotherapy and prior to surgery, aiming to find the most
efficient modality to predict the response to neoadjuvant chemotherapy of the primary breast
cancer and its possible lymph node metastases. Post-surgical histology and a 6 month
follow-up (to detect occult metastases) will constitute the standard of truth for
determination and comparison of diagnostic performances.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Determine and compare sensitivity and specificity of 3 different modalities for the prediction of effectiveness of neoadjuvant chemotherapy
Determine and compare sensitivity and specificity of 3 different modalities for the prediction of effectiveness of neoadjuvant chemotherapy
during de study
Yes
Jean-Noël TALBOT, Pr,MD,PhD
Principal Investigator
Assistance Publique - Hôpitaux de Paris
France: Ministry of Health
P020907
NCT00236275
May 2004
December 2007
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